Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Obesity01:24

Obesity

1.1K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.1K
Regulation of Food Intake01:30

Regulation of Food Intake

2.2K
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
2.2K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

385
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
385
Stress and Mental Health01:30

Stress and Mental Health

446
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
446

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exposure to false cardiac feedback alters pain perception and anticipatory cardiac frequency.

eLife·2026
Same author

Impaired pendulum-like mechanics during post-stroke walking: a biomechanical comparison with healthy individuals.

Frontiers in neurology·2026
Same author

Digital monitoring of motor function in Parkinson's disease using Markerless motion analysis and exergaming.

Frontiers in neurology·2026
Same author

Breathing Strategies to Influence Perception: Evidence for Interoceptive and Exteroceptive Active Sensing.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same author

Nutritional knowledge in patients with severe obesity during a residential rehabilitation: the relationships with socio-demographic variables.

Journal of endocrinological investigation·2026
Same author

Progression of acromegalic joint and psychological complications according to sex, treatments, and disease control.

European journal of endocrinology·2026

Related Experiment Video

Updated: Jan 4, 2026

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

25.8K

Altered temporal sensitivity in obesity is linked to pro-inflammatory state.

Federica Scarpina1, Paolo Marzullo2,3, Stefania Mai2

  • 1Istituto Auxologico Italiano, I.R.C.C.S., Ospedale San Giuseppe, Piancavallo, Italy. f.scarpina@auxologico.it.

Scientific Reports
|October 31, 2019
PubMed
Summary

Obesity impairs temporal sensitivity, with the inflammatory cytokine leptin significantly predicting these deficits. This suggests the immune system, not just brain dysfunction, influences time perception in obesity.

More Related Videos

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study
03:05

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study

Published on: November 21, 2025

421
An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function
09:20

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function

Published on: May 4, 2021

4.1K

Related Experiment Videos

Last Updated: Jan 4, 2026

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

25.8K
Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study
03:05

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study

Published on: November 21, 2025

421
An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function
09:20

An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function

Published on: May 4, 2021

4.1K

Area of Science:

  • Neuroscience
  • Psychology
  • Immunology

Background:

  • Obesity is linked to reduced temporal sensitivity to multisensory stimuli.
  • Pro-inflammatory states, characterized by elevated leptin and IL6, are common in obesity.
  • The role of inflammation in altered temporal processing in obesity requires further investigation.

Purpose of the Study:

  • To investigate the influence of the pro-inflammatory state on temporal sensitivity alterations in obesity.
  • To examine the relationship between serum levels of inflammatory markers (leptin, IL6) and neurotrophic factors (BDNF, S100SB) with temporal performance.
  • To compare audiovisual temporal judgment in individuals with obesity and normal-weight controls.

Main Methods:

  • Comparison of performance on simultaneity judgment and temporal order judgment tasks between 15 obese males and 15 normal-weight males.
  • Quantification of serum levels of leptin, IL6, BDNF, and S100SB.
  • Statistical analysis to identify predictors of behavioral differences.

Main Results:

  • Individuals with obesity exhibited poorer temporal sensitivity compared to normal-weight controls.
  • Elevated leptin levels were the strongest predictor of impaired performance in both temporal tasks.
  • Serum levels of IL6, BDNF, and S100SB did not show significant correlations with behavioral outcomes.

Conclusions:

  • The pro-inflammatory state, particularly elevated leptin, plays a significant role in reduced temporal sensitivity observed in obesity.
  • Immune system dysregulation, rather than general cerebral dysfunction, may underlie altered temporal processing in obesity.
  • Cytokines likely influence brain mechanisms critical for temporal sensitivity, warranting further research into neuro-immune interactions.