Related Experiment Video
Updated: Jun 28, 2026

Simultaneous Measurements of Intracellular Calcium and Membrane Potential in Freshly Isolated and Intact Mouse Cerebral Endothelium
Published on: January 20, 2019
Salomón Hakim: the man behind normal pressure hydrocephalus
Matheus Kahakura Franco Pedro1, Joseph Franklin Chenisz da Silva2, Samanta Fabricio Blattes da Rocha3
1Instituto de Neurologia de Curitiba, Departamento de Neurologia, Curitiba PR, Brasil.
Professor Salomón Hakim pioneered the understanding of normal pressure hydrocephalus and its treatment with ventricular shunting. His work demonstrated that certain dementias, previously untreatable, could be effectively managed.
Area of Science:
- Neurology
- Neurosurgery
- Geriatrics
Background:
- Professor Salomón Hakim's seminal contributions to neurology.
- The development of the concept of normal pressure hydrocephalus (NPH).
- Establishing ventricular shunting as a viable treatment for NPH.
Discussion:
- Review of Hakim's groundbreaking research on NPH.
- Impact of Hakim's work on the understanding of dementia.
- Historical perspective on the treatment of cognitive decline.
Key Insights:
- Normal pressure hydrocephalus is a treatable neurological condition.
- Ventricular shunting offers effective management for NPH.
- Some forms of dementia were misdiagnosed as senility.
Outlook:
- Hakim's legacy continues to shape dementia research.
- Ongoing influence of his work on neurosurgical interventions.
- Future directions in the study and treatment of hydrocephalus and dementia.
Related Concept Videos
Cerebrospinal Fluid
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain.
Increased Intracranial Pressure l: Introduction
Increased Intracranial Pressure ll: Pathophysiology
Cerebral Edema l: Introduction
Cerebral Edema ll: Pathophysiology
Cytotoxic Edema: Pathophysiology

