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Long non-coding RNAs in cardiac hypertrophy
1Cardiovascular Disease Research Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Haidian District, Beijing, 100091, China.
Insights
Cardiac hypertrophy (CH) involves adaptive responses that can progress to heart failure (HF). Long non-coding RNAs (lncRNAs) are increasingly recognized as key regulators in CH, offering novel therapeutic targets.
Area of Science:
- Cardiology
- Molecular Biology
- Genetics
Background:
- Cardiac hypertrophy (CH) is an adaptive response to cardiac stress, but prolonged stimulation can lead to heart failure (HF).
- The precise molecular mechanisms underlying CH remain incompletely understood.
- Long non-coding RNAs (lncRNAs) have emerged as critical players in cardiovascular diseases.
Purpose of the Study:
- To explore the role of lncRNAs in the molecular mechanisms of cardiac hypertrophy.
- To identify potential therapeutic targets for CH based on lncRNA regulation.
Main Methods:
- Literature review and analysis of recent evidence on lncRNAs in CH.
- Investigating the diverse mechanisms by which lncRNAs influence CH progression.
- Examining the potential for lncRNA expression modulation to treat CH.
Main Results:
- Evidence indicates that various lncRNAs significantly impact CH.
- Different lncRNAs exert opposing effects, either promoting or inhibiting CH.
- Modulating lncRNA expression shows promise in ameliorating CH.
Conclusions:
- lncRNAs are pivotal in the pathogenesis of cardiac hypertrophy.
- Targeting lncRNAs represents a promising novel therapeutic strategy for CH.
- Further research into CH-related lncRNAs is warranted.
Abstract:
Cardiac hypertrophy (CH) is generally considered adaptive responses that may occur after myocardial infarction, pressure overload, volume overload, inflammatory heart muscle disease, or idiopathic dilated cardiomyopathy, whereas long-term stimulation eventually leads to heart failure (HF). However, the current molecular mechanisms involved in CH are unclear. Recently, increasing evidences reveal that long non-coding RNAs (lncRNAs) play vital roles in CH. Different lncRNAs can promote or inhibit the pathological process of CH by different mechanisms, while the regulation of lncRNAs expression can improve CH. Thus, CH-related lncRNAs may become a novel field of research on CH.
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