Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Electron Microscope Tomography and Single-particle Reconstruction01:07

Electron Microscope Tomography and Single-particle Reconstruction

2.8K
Transmission electron microscopy (TEM) can be used to determine the 3D structure of biological samples with the help of techniques such as electron microscope tomography and single-particle reconstruction. While single-particle reconstruction can examine macromolecules and macromolecular complexes in vitro conditions only, tomography permits the study of cell components or small cells in vivo.
Electron Tomography
Electron tomography can be performed either in TEM or STEM (scanning transmission...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

FOLR1-targeted actinium-225-based alpha-particle therapy eliminates ovarian cancer.

Science advances·2026
Same author

Topical resiquimod elicits systemic protection and improves anti-PD1 therapy in melanoma via priming of CD8+ T cells.

Cancer immunology research·2026
Same author

Estrogen receptor β target gene expression reveals novel repressive functions in aggressive breast cancer.

NPJ breast cancer·2026
Same author

FOLR1-targeted Actinium-225-based Alpha-particle Therapy Eliminates Ovarian Cancer.

bioRxiv : the preprint server for biology·2025
Same author

Preliminary evaluation of the safety and feasibility of toll-like receptor ligand CB101 combined with hypofractionated radiation therapy in canine head and neck cancer: a pilot study.

Veterinary oncology (London, England)·2025
Same author

Enhancing outcomes in medically inoperable early-stage NSCLC with gut-targeted antibiotics and stereotactic body radiotherapy: results from a randomized pilot study.

Journal for immunotherapy of cancer·2025

Related Experiment Video

Updated: Jan 4, 2026

Quantitative Visualization and Detection of Skin Cancer Using Dynamic Thermal Imaging
06:08

Quantitative Visualization and Detection of Skin Cancer Using Dynamic Thermal Imaging

Published on: May 5, 2011

17.2K

Cherenkov imaging for total skin electron therapy (TSET).

Yunhe Xie1,2, Heather Petroccia1, Amit Maity1

  • 1Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Medical Physics
|October 31, 2019
PubMed
Summary

Cherenkov imaging visualizes radiation beams during total skin electron therapy (TSET), offering real-time dose uniformity assessment. This method validates patient-specific dose distributions, improving treatment accuracy.

Keywords:
biomedical opticscherenkov imagingradiation therapytotal skin electron therapy

More Related Videos

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
09:37

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

2.8K
Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model
05:08

Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model

Published on: February 17, 2019

6.5K

Related Experiment Videos

Last Updated: Jan 4, 2026

Quantitative Visualization and Detection of Skin Cancer Using Dynamic Thermal Imaging
06:08

Quantitative Visualization and Detection of Skin Cancer Using Dynamic Thermal Imaging

Published on: May 5, 2011

17.2K
Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
09:37

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

2.8K
Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model
05:08

Targeted and Selective Treatment of Pluripotent Stem Cell-derived Teratomas Using External Beam Radiation in a Small-animal Model

Published on: February 17, 2019

6.5K

Area of Science:

  • Medical Physics
  • Radiation Oncology

Background:

  • Total skin electron therapy (TSET) treats widespread skin malignancies using high-energy electrons.
  • Optical Cherenkov photons, emitted from electron-tissue interactions, visualize the otherwise invisible radiation beam.

Purpose of the Study:

  • To evaluate Cherenkov imaging as a real-time method for assessing dose uniformity in TSET.
  • To validate Cherenkov imaging against in vivo dosimetry measurements.

Main Methods:

  • A time-gated intensified camera system captured Cherenkov emissions from 15 TSET patients.
  • In vivo detectors (IVD) in nine locations monitored dose.
  • Perspective and inverse square corrections were developed for Cherenkov imaging.

Main Results:

  • Cherenkov imaging produced 2D maps proportional to surface dose.
  • Corrected Cherenkov imaging showed good agreement with IVD measurements.
  • The ratio between chest and umbilicus points had a 2.4% standard deviation compared to OSLD measurements.

Conclusions:

  • Cherenkov imaging is a viable tool for real-time dose validation in TSET.
  • The developed corrections enhance the accuracy of Cherenkov imaging for patient-specific dose distributions.