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Updated: Jan 4, 2026
Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
Published on: August 16, 2016
Simultaneous High-Resolution Detection of Bioenergetic Molecules using Biomimetic-Receptor Nanopore
Zhuoqun Su1, Yongfeng Wei1, Xiao-Feng Kang1
1Key Laboratory of Synthetic and Natural Functional Molecular Chemistry, College of Chemistry & Materials Science , Northwest University , Xi'an 710069 , P. R. China.
Abstract:
A novel artificial receptor, heptakis-[6-deoxy-6-(2-hydroxy-3-trimethylammonion-propyl) amino]-beta-cyclomaltoheptaose, with similar functions of mitochondrial ADP/ATP carrier protein, was synthesized and harbored in the engineered α-HL (M113R)7 nanopore, forming a single-molecule biosensor for sensing bioenergetic molecules and their transformations. The strategy significantly elevates both selectivity and signal-to-noise, which enables simultaneous recognition and detection of ATP, ADP, and AMP by real-time single-molecule measurement.
