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The liver peptides after chronic administration of ethanol in rats
1Department of Inorganic and Analytical Chemistry, Medical Academy, Bialystok, Poland.
Alcohol and Alcoholism (Oxford, Oxfordshire)
|January 1, 1988
Abstract:
The liver peptide fractions labelled with 3H-arginine after chronic administration of ethanol to rats have been analysed by gel filtration chromatography and tlc. Specific 3H-arginine radioactivity in the liver peptide fraction calculated per micrograms of alpha-amino nitrogen was significantly decreased by alcohol. The amount of peptide spots obtained by tlc in the ethanol-treated group was reduced in comparison with the control group. The findings suggest a change in the protein metabolism in hepatic dysfunction in rats receiving ethanol over a prolonged period.