Jove
Visualize
Contact Us

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nitrogen-Doped Graphene Quantum Dots Conjugated to Leucettinib-21 Rescue Differentiating Zebrafish Purkinje Cells by Inhibiting Dyrk1A Kinase.

ACS applied nano materials·2026
Same author

Cognitive ethology of nest building in a shell-dwelling cichlid.

Current biology : CB·2026
Same author

Genomic Organization, Evolutionary Conservation and Expression of <i>Ataxin-2</i> and <i>Ataxin-2-like</i> Genes Underscore the Suitability of Zebrafish as a Model Organism for SCA2 and Related Diseases.

Biomedicines·2025
Same author

Intrinsic timing of brood care in shell-dwelling cichlids.

Current biology : CB·2025
Same author

Genetic modeling of degenerative diseases and mechanisms of neuronal regeneration in the zebrafish cerebellum.

Cellular and molecular life sciences : CMLS·2024
Same author

In Vivo Monitoring of <i>Fabp7</i> Expression in Transgenic Zebrafish.

Cells·2024
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jan 4, 2026

In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

21.2K

Neurological Disease Modelling for Spinocerebellar Ataxia Using Zebrafish.

Kazuhiko Namikawa1, Alessandro Dorigo1, Reinhard W Köster1

  • 1Cellular and Molecular Neurobiology, Zoological Institute, Technische Universität Braunschweig, Braunschweig, Germany.

Journal of Experimental Neuroscience
|November 1, 2019
PubMed
Summary
This summary is machine-generated.

Zebrafish models of spinocerebellar ataxias (SCAs) were developed using a Purkinje cell-specific element. These models mimic SCA neuropathology and motor deficits, offering insights into disease mechanisms.

Keywords:
Purkinje neuronsZebrafishdisease modellingneurodegenerationspinocerebellar degeneration

More Related Videos

The Three-Chamber Choice Behavioral Task using Zebrafish as a Model System
07:55

The Three-Chamber Choice Behavioral Task using Zebrafish as a Model System

Published on: April 14, 2021

4.3K
Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy
08:26

Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy

Published on: October 19, 2021

6.2K

Related Experiment Videos

Last Updated: Jan 4, 2026

In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

21.2K
The Three-Chamber Choice Behavioral Task using Zebrafish as a Model System
07:55

The Three-Chamber Choice Behavioral Task using Zebrafish as a Model System

Published on: April 14, 2021

4.3K
Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy
08:26

Behavioral And Physiological Analysis In A Zebrafish Model Of Epilepsy

Published on: October 19, 2021

6.2K

Area of Science:

  • Neuroscience
  • Genetics
  • Developmental Biology

Background:

  • The cerebellum integrates sensory and motor functions, with conserved cytoarchitecture between zebrafish and mammals.
  • Zebrafish offer potential for modeling human cerebellar diseases, particularly spinocerebellar ataxias (SCAs).
  • SCAs are inherited neurodegenerative diseases primarily affecting cerebellar Purkinje cells (PCs), leading to motor discoordination.

Purpose of the Study:

  • To establish zebrafish models for studying SCAs, specifically SCA type 13 (SCA13).
  • To investigate the cell-biological mechanisms underlying SCA13 pathogenesis in vivo.
  • To enable high-resolution in vivo imaging of affected cerebellar PCs.

Main Methods:

  • Identification of a Purkinje cell-specific regulatory element for tunable gene expression.
  • Development of coexpression vectors for in vivo imaging of SCA-affected PCs.
  • Generation of zebrafish expressing SCA13 transgenes to study PC degeneration.

Main Results:

  • SCA13 transgene expression in zebrafish led to cell-autonomous Purkinje cell degeneration.
  • SCA13-induced PC degeneration resulted in observable eye movement deficits.
  • The zebrafish models recapitulated key neuropathological features and motor control loss seen in SCA-affected brains.

Conclusions:

  • Zebrafish are a powerful model for studying SCAs, including SCA13.
  • SCA13 zebrafish models facilitate the investigation of cell-autonomous pathogenic mechanisms.
  • This approach aids in unraveling the cytotoxic pathways involved in SCAs.