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Evaluation of Relation between HbA1c Level with Cognitive Disorders and Depression in Type 2 Diabetes Mellitus

Masoud Doroodgar1, Moein Doroodgar2, Shahnaz Tofangchiha3

  • 1Department of Internal Medicine, AJA University of Medical Sciences, Tehran, Iran.

Open Access Macedonian Journal of Medical Sciences
|November 1, 2019
PubMed

Insights

This study found no significant link between HbA1c levels and overall cognitive decline or depression in type 2 diabetes patients. However, recent memory impairment was linked to higher HbA1c levels.

Area of Science:

  • Endocrinology
  • Neurology
  • Psychiatry

Background:

  • Previous studies suggest a link between HbA1c levels and cognitive decline/depression in type 2 diabetes.
  • The relationship between glycemic control and neurological/psychiatric outcomes requires further investigation.

Purpose of the Study:

  • To investigate the association between HbA1c levels and cognitive function/depression in type 2 diabetes patients.
  • To determine if glycemic control impacts cognitive decline and mood disorders.

Main Methods:

  • A descriptive-analytic study involving 512 type 2 diabetes patients.
  • Cognitive function assessed using the Mini-Mental Status Exam (MMSE).
  • Depressive disorders evaluated with the Patient Health Questionnaire-9 (PHQ-9).

Main Results:

  • Mean HbA1c was 7.58%, mean MMSE score was 27.28.
  • 83.3% of patients experienced depressive disorders; 8.59% had MMSE scores below 24.
  • No significant association found between overall HbA1c and cognitive problems, but recent memory decline showed a significant relationship with HbA1c (P=0.03).

Conclusions:

  • While overall cognitive function and depression showed no significant link to HbA1c levels, recent memory is notably affected in type 2 diabetes patients.
  • These patients exhibit a higher prevalence of depressive disorders.
  • The findings highlight the specific impact of glycemic control on recent memory in type 2 diabetes.
Abstract

Keywords:
CognitionDepressionHbA1cType 2 Diabetes

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