Reclassifying Pseudopolyps in Inflammatory Bowel Disease: Histologic and Endoscopic Description in the New Era of
Mona Rezapour1, Maria Alejandra Quintero2, Nidah S Khakoo3
1Department of Gastroenterology and Hepatology, University of California Los Angeles, Los Angeles, California.
Introduction:
In this study, we identify the frequency of pseudopolyps (PPs) with normal histology and their association to surrounding tissue.
Methods:
Patients were enrolled in a study identifying endoscopic characteristics of PPs (n = 29) or were collected as part of our IBD biobank (n = 16). Statistical analysis included Stata v.15.0. chi-square and Student t-test.
Results:
A total of 45 patients with 117 PP biopsies were identified. More patients with healed PP were in endoscopic remission compared with those with inflammatory PP (82.6% vs 17.4%, respectively).
Conclusion:
This is the first study to find mucosal healing of PPs and its association with deep remission.
Insights
This study found that pseudopolyps (PPs) with normal histology are associated with mucosal healing. Healed PPs were more common in patients achieving endoscopic remission, suggesting a link between PPs and deep remission.
Area of Science:
- Gastroenterology
- Endoscopy
- Histopathology
Background:
- Pseudopolyps (PPs) are common findings during endoscopic procedures.
- Understanding the histological characteristics and associations of PPs is crucial for patient management.
- This study investigates the frequency of PPs with normal histology and their relationship with surrounding tissues.
Purpose of the Study:
- To determine the frequency of pseudopolyps (PPs) exhibiting normal histology.
- To explore the association between pseudopolyps and their surrounding tissue.
- To investigate the relationship between pseudopolyp healing and endoscopic remission in patients.
Main Methods:
- Retrospective analysis of 45 patients with 117 pseudopolyp (PP) biopsies.
- Patients were identified through a study on endoscopic characteristics of PPs or an inflammatory bowel disease (IBD) biobank.
- Statistical analysis included chi-square and Student t-tests using Stata v.15.0.
Main Results:
- A total of 45 patients and 117 pseudopolyp (PP) biopsies were analyzed.
- A higher proportion of patients with healed PPs were in endoscopic remission compared to those with inflammatory PPs (82.6% vs 17.4%).
Conclusions:
- This research is the first to report on mucosal healing of pseudopolyps (PPs).
- The findings suggest an association between pseudopolyp healing and achieving deep remission in patients.
- Further investigation into the clinical implications of pseudopolyp histology and healing is warranted.
More Related Videos
15:49Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
Published on: October 16, 2013
08:52Performing Colonoscopic-Guided Pinch Biopsies in Mice and Evaluating Subsequent Tissue Changes
Published on: February 5, 2021
Related Concept Videos
01:30Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
01:21Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
01:17Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
01:27Histology of the Small Intestine
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...