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[Humoral response in Leishmania infantum clinical infections]
A Berneman1, X Rolland, G Broun
1Institut de Technologie des surfaces actives, Université de Technologie de Compiègne, France.
Annales De L'Institut Pasteur. Immunology
|May 1, 1988
Abstract:
We sought a specific humoral response in man in order to find an antigenic marker of Leishmania infantum infection. This study was carried out by the Western blot technique; 42 sera from human patients were analysed on a standard electrophoretic pattern (SDS-PAGE) of L. infantum antigens. Patient sera reacted specifically with 4 (160-, 140-, 94- and 79-Kd) antigens, and reactive antibodies were IgG. We suggest that these antigens may be used for diagnosis of L. infantum visceral leishmaniasis.