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Updated: Jan 4, 2026

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

High Angular Resolution Diffusion MRI Reveals Conserved and Deviant Programs in the Paths that Guide Human Cortical

Christine J Charvet¹, Avilash Das^2,3,4, Jae W Song⁵

¹Department of Psychology, Delaware State University, Dover, DE 19901, USA.

Cerebral Cortex (New York, N.Y. : 1991)

|November 1, 2019

Summary

This summary is machine-generated.

Human and mouse brain development reveals distinct pathways. Early human cortical development shows unique radial glial organization, while the corpus callosum shows divergent growth patterns, highlighting evolutionary differences in brain development.

Keywords:

brain pathways callosal cingulum diffusion MRI fetus human mouse tractography

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Area of Science:

Neuroscience
Developmental Biology
Comparative Anatomy

Background:

Diffusion MR tractography enables investigation of conserved and deviant developmental programs across species.
Understanding evolutionary changes in brain development requires comparative studies between humans and model organisms like mice.

Purpose of the Study:

To investigate evolutionary changes in radial organization and emerging pathways between human and mouse brains during fetal development.
To compare radial glial and commissural development, specifically the corpus callosum, between humans, macaques, and mice.

Main Methods:

Acquisition of high angular resolution diffusion MR scans of mice (embryonic day 10.5 to postnatal week 4) and human brains (gestational week 17-30).
Comparative analysis of radial glial development and corpus callosum growth trajectories across species.

Main Results:

Human developing cortex (gestational week 17-20) exhibits prominent pathways associated with radial glial organization, less evident in age-matched mice.
Early corpus callosum development follows a similar timetable in primates (humans, macaques) and rodents (mice).
The corpus callosum shows a significantly extended growth period in primates compared to rodents.

Conclusions:

Human and mouse brains exhibit deviant developmental programs, particularly in the emergence of cortical pathways.
Comparative analysis highlights species-specific divergence in brain development, especially concerning radial organization and corpus callosum maturation.