Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Establishing a living systematic review of characterisation and parameter reporting in lithium-ion and lithium-sulfur cathode research.

Discover electrochemistry·2026
Same author

Recommendations for HLA Genotyping Data Standards and Clinical Laboratory Staffing Considerations.

HLA·2026
Same author

Do conditional marketing authorisations actually accelerate patient access? Time-to-access of conditional vs. standard marketing authorisations in Italy, Spain, and Germany.

Journal of pharmaceutical policy and practice·2026
Same author

Phase I multi-center clinical and biomarker study of the dual-action androgen receptor inhibitor ONCT-534.

Investigational new drugs·2026
Same author

Nomenclature for Factors of the HLA System, 2026.

HLA·2026
Same author

Experimental quantification of resistance to subsidence conferred by endplate-specific expandable implants in anterior lumbar interbody fusion.

Journal of orthopaedic surgery and research·2026
Same journal

Correction to 'New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress'.

Nucleic acids research·2026
Same journal

VeloRM: disentangling pre- and post-splicing RNA modification dynamics at single-cell resolution.

Nucleic acids research·2026
Same journal

Accessibility of telomeric overhangs to stabilizing small-molecule ligands.

Nucleic acids research·2026
Same journal

Multivalent interactions mediate SNAIL transcription factor stimulation of the nucleosome deacetylase activity of the CoREST complex.

Nucleic acids research·2026
Same journal

Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions and transcription start sites.

Nucleic acids research·2026
Same journal

Correction to 'The Gene Ontology knowledgebase in 2026'.

Nucleic acids research·2026
See all related articles

Related Experiment Video

Updated: Jan 4, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
08:07

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

10.5K

IPD-IMGT/HLA Database.

James Robinson1,2, Dominic J Barker1, Xenia Georgiou1

  • 1Anthony Nolan Research Institute, London, UK.

Nucleic Acids Research
|November 1, 2019
PubMed
Summary
This summary is machine-generated.

The IPD-IMGT/HLA Database provides access to over 25,000 human Major Histocompatibility Complex (MHC) gene variants. This resource is crucial for transplantation success, managing increasing data complexity and discovery rates.

More Related Videos

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
09:02

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

22.2K
A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research
08:17

A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research

Published on: August 15, 2019

15.2K

Related Experiment Videos

Last Updated: Jan 4, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
08:07

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

10.5K
Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
09:02

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

22.2K
A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research
08:17

A Human Peripheral Blood Mononuclear Cell PBMC Engrafted Humanized Xenograft Model for Translational Immuno-oncology I-O Research

Published on: August 15, 2019

15.2K

Area of Science:

  • Immunogenetics
  • Genomics
  • Bioinformatics

Background:

  • The Major Histocompatibility Complex (MHC) is the most polymorphic region in the human genome.
  • The IPD-IMGT/HLA Database houses over 25,000 allele sequences for 45 MHC genes.
  • Some MHC genes exhibit hyperpolymorphism, with thousands of identified variants.

Purpose of the Study:

  • To provide a stable, accessible, and user-friendly repository for human MHC gene sequence variants.
  • To support the scientific and medical communities with critical data for transplantation.
  • To address the challenges of managing an increasing volume and complexity of genetic sequence data.

Main Methods:

  • Curating and publishing a large collection of human MHC allele sequences.
  • Developing custom tools for data management and accessibility.
  • Maintaining a dedicated resource for hyperpolymorphic gene variants.

Main Results:

  • The database currently contains over 25,000 allele sequences for 45 MHC genes.
  • It serves as a critical resource for understanding genetic diversity in the MHC region.
  • The resource facilitates research and clinical applications, particularly in transplantation.

Conclusions:

  • The IPD-IMGT/HLA Database is essential for managing and accessing highly polymorphic MHC gene data.
  • Continued development of custom tools is necessary to handle the growing complexity and submission rates.
  • Innovative data access and presentation methods are required to keep pace with new discoveries in human immunogenetics.