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Related Experiment Video

Updated: Jan 4, 2026

Author Spotlight: Advancing Corneal Innervation Research Through Innovative Models

Author Spotlight: Advancing Corneal Innervation Research Through Innovative Models

Published on: December 8, 2023

[Corneal neurotization].

J N Lueke¹, C Holtmann², K Beseoglu³

¹Klinik für Augenheilkunde, Universitätsklinikum Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Deutschland.

Der Ophthalmologe : Zeitschrift Der Deutschen Ophthalmologischen Gesellschaft

|November 1, 2019

Summary

This summary is machine-generated.

Neurotrophic keratopathy (NK) treatment is improved by corneal neurotization, a nerve transfer technique. This surgical approach re-establishes corneal sensation and healing in severe cases.

Keywords:

Cornea Nerve transfer Neurotization Neurotrophic keratopathy Ulcer

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Corneal Tissue Engineering: An In Vitro Model of the Stromal-nerve Interactions of the Human Cornea

Corneal Tissue Engineering: An In Vitro Model of the Stromal-nerve Interactions of the Human Cornea

Published on: January 24, 2018

Area of Science:

Ophthalmology
Neurosurgery
Regenerative Medicine

Background:

Neurotrophic keratopathy (NK) presents limited treatment options.
Severe NK cases often require surgical interventions like amnionic membrane transplantation or tarsorrhaphy.

Purpose of the Study:

To describe corneal neurotization as a novel surgical treatment for neurotrophic keratopathy.
To detail the technique of supraorbital nerve transposition for restoring corneal nerve function.

Main Methods:

Corneal neurotization involves transposing a donor nerve along the limbal circumference.
The supraorbital nerve was directly transposed in the described procedure.
An alternative method uses a sural nerve interponate.

Main Results:

Corneal neurotization aims to re-establish corneal sensation.
This technique promotes trophic function, aiding in corneal healing.
Successful nerve transfer can improve outcomes for severe NK.

Conclusions:

Corneal neurotization offers a promising surgical solution for neurotrophic keratopathy.
Supraorbital nerve transposition is a viable technique for nerve reconstruction in the cornea.
This approach addresses the limitations of previous treatments for severe NK.