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Updated: Jan 4, 2026
07:16
Biochemical Titration of Glycogen In vitro
Published on: November 24, 2013
28.8K
Brain Glycogen Structure and Its Associated Proteins: Past, Present and Future
M Kathryn Brewer1, Matthew S Gentry2
1Department of Molecular and Cellular Biochemistry, Epilepsy and Brain Metabolism Center, Lafora Epilepsy Cure Initiative, and Center for Structural Biology, University of Kentucky College of Medicine, Lexington, KY, USA.
Advances in Neurobiology
|November 1, 2019
Summary
This chapter explores glycogen, a key glucose storage molecule, detailing its structure, properties, and regulation, with a special emphasis on brain tissue research.
Area of Science:
- Biochemistry
- Neuroscience
- Molecular Biology
Background:
- Glycogen is the primary glucose-storage polysaccharide in animals.
- Understanding glycogen metabolism is crucial for cellular energy homeostasis.
- Previous research has laid the groundwork for detailed molecular investigations.
Purpose of the Study:
- To provide a comprehensive historical overview of glycogen research.
- To elucidate the intricate structure, regulation, and properties of glycogen.
- To examine the subcellular distribution of glycogen and associated proteins, particularly in neural tissues.
Main Methods:
- Literature review of historical and current glycogen research.
- Detailed analysis of biochemical and structural data.
- Focus on proteomic and cellular localization studies in brain tissue.
Main Results:
- Glycogen structure and its dynamic regulation are complex.
- Associated proteins play critical roles in glycogen synthesis and degradation.
- Specific patterns of glycogen distribution exist within brain cells.
Conclusions:
- Glycogen is a dynamic and highly regulated energy reserve.
- Associated proteins are essential for glycogen function.
- Further research into brain glycogen is warranted for understanding neurological functions and diseases.
Keywords:
AmylopectinGlycogen architectureGlycogen structureGlycophagyLafora diseasePolyglucosanPompe diseaseStarchMore Related Videos
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