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Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products
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[Genomics approaches decode natural products synthesis].

Haotian Chi1, Shi Chen1

  • 1Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, Hubei, China.

Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology
|November 1, 2019
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Discovering new drugs from natural products is crucial, especially with rising antibiotic resistance. Genomics and advanced techniques help unlock hidden microbial compounds, but overcoming cultivation challenges is key.

Keywords:
biological chassisgenome mininggenomicsnatural products

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Area of Science:

  • Natural Product Discovery
  • Drug Development
  • Genomics

Background:

  • Novel natural products are primary sources for new drug discovery.
  • Genomics advancements have revealed vast, untapped natural product potential in organisms.
  • Challenges in laboratory cultivation limit the realization of this potential.

Purpose of the Study:

  • To review strategies for discovering novel natural products.
  • To address the challenge of silent biosynthetic gene clusters.
  • To discuss overcoming limitations in natural product drug discovery.

Main Methods:

  • Genome mining for natural product biosynthetic gene clusters.
  • Induction of silent or low-expressed biosynthetic gene clusters.
  • Construction and utilization of engineered biological chassis.

Main Results:

  • Genomics provides a roadmap to identify potential natural product producers.
  • Metabolic engineering and synthetic biology can activate silent gene clusters.
  • Biological chassis enable heterologous expression and production of valuable compounds.

Conclusions:

  • Integrating genomics, cultivation strategies, and synthetic biology is essential.
  • These integrated approaches can unlock new drug candidates to combat antibiotic resistance.
  • Overcoming cultivation barriers is critical for realizing the full potential of natural products.