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Two case reports of delayed-allergic reactions to clindamycin confirmed with a positive lymphocyte transformation
F Vílchez-Sánchez1, J Domínguez-Ortega1,2, M González Muñoz3
1Department of Allergy, Hospital La Paz Institute for Health Research (IdiPaz), Madrid, Spain.
Summary:
Clindamycin is widely used in the prophylaxis and treatment of infections due to its broad spectrum of antimicrobial activity. Hypersensitivity to clindamycin seems to be not very common (less than 1% of drug-allergic reactions) and it mostly appears as delayed T-cell mediated. For the diagnosis, skin testing is considered to be highly sensitive and rather safe, but cutaneous and systemic reactions have been described. Provocation test is considered the gold standard. However, it includes the possibility of severe reactions. We reported two cases of delayed allergic reaction to clindamycin, confirmed with a positive lymphocyte transformation test, showing this in vitro test like a promising diagnostic method because of its usefulness and safety.
Insights
Delayed hypersensitivity to clindamycin is uncommon but can occur. A lymphocyte transformation test offers a safe and effective in vitro method for diagnosing clindamycin allergy, avoiding risks associated with traditional tests.
Area of Science:
- Clinical immunology
- Infectious diseases
- Pharmacology
Background:
- Clindamycin is a broad-spectrum antibiotic frequently used for infection prophylaxis and treatment.
- Hypersensitivity reactions to clindamycin are infrequent, typically manifesting as delayed, T-cell mediated responses.
- Current diagnostic methods like skin testing and provocation tests carry risks of adverse reactions.
