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Related Experiment Video

Updated: Jan 4, 2026

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

Weaning from Parenteral Nutrition.

Andrew Ukleja¹

¹Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center/Beth Israel Lahey Health, 330 Brookline Ave., Boston, MA 02215, USA.

Gastroenterology Clinics of North America

|November 1, 2019

Summary

Achieving enteral autonomy by weaning patients off parenteral nutrition (PN) and intravenous fluids (IV) is the primary goal for short bowel syndrome/intestinal failure. Individualized weaning strategies, potentially including teduglutide, are crucial for success and long-term monitoring.

Keywords:

GLP-2 Growth hormone Intestinal failure Parenteral nutrition Parenteral support Short bowel syndrome Teduglutide (Gattex)Treatment

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Area of Science:

Gastroenterology
Clinical Nutrition
Parenteral Nutrition

Background:

Short bowel syndrome (SBS) and intestinal failure (IF) necessitate parenteral nutrition (PN) and intravenous (IV) fluid support.
The ultimate treatment goal is to achieve enteral autonomy, eliminating the need for PN/IV.
PN/IV dependency poses risks including infection, thrombosis, and metabolic complications.

Purpose of the Study:

To outline clinical considerations for the safe and successful weaning of patients from PN/IV.
To discuss strategies for optimizing diet, hydration, and medical management prior to and during PN/IV weaning.
To highlight the importance of patient selection and long-term monitoring post-weaning.

Main Methods:

Review of current clinical practices and evidence for PN/IV weaning in SBS/IF.
Discussion of pharmacological interventions, including teduglutide, for PN/IV reduction and elimination.
Emphasis on individualized patient assessment and management protocols.

Main Results:

Successful PN/IV weaning is achievable in select SBS/IF patients through optimized management.
Teduglutide shows promise in reducing PN/IV volume and facilitating weaning, though further evaluation is needed.
Long-term nutritional monitoring is essential following PN/IV elimination to prevent deficiencies.

Conclusions:

Individualized, multidisciplinary approaches are key to successful PN/IV weaning in SBS/IF.
Careful patient selection and ongoing monitoring are critical for managing risks and ensuring long-term outcomes.
Further research on optimal patient selection and long-term safety of agents like teduglutide is warranted.