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Focus on FKBP51: A molecular link between stress and metabolic disorders

Alexander S Häusl1, Georgia Balsevich2, Nils C Gassen3

  • 1Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, 80804, Munich, Germany.

Molecular Metabolism
|November 1, 2019
PubMed
Abstract

Insights

FKBP51 is a promising target for treating obesity and type 2 diabetes (T2D). Targeting FKBP51 may offer new therapies for metabolic syndrome symptoms linked to chronic stress and depression.

Area of Science:

  • Metabolic disorders and psychiatric conditions research
  • Molecular mechanisms of stress and metabolism

Background:

  • Obesity, Type 2 Diabetes (T2D), and stress-related disorders pose significant public health challenges.
  • Chronic stress and depression are linked to metabolic syndrome, but molecular links are unclear.
  • FKBP51 is identified as a potential therapeutic target for psychiatric and metabolic conditions.

Purpose of the Study:

  • To review evidence on FKBP51's role in metabolism.
  • To highlight FKBP51's therapeutic potential for metabolic syndrome.
  • To explore FKBP51 as a drug target for stress-related obesity and T2D.

Main Methods:

  • In vitro studies
  • Preclinical studies
  • Human studies

Main Results:

  • FKBP51 is implicated in metabolic regulation.
  • Evidence supports FKBP51's role in stress-related disorders.
  • FKBP51 shows therapeutic promise for metabolic syndrome.

Conclusions:

  • FKBP51 is a viable drug target for stress-related obesity and T2D.
  • Further research is needed to bridge knowledge gaps.
  • Implementing FKBP51 as a therapeutic target requires continued investigation.
Keywords:
AdipogensisFKBP51Glucose uptakeObesitySAFit2StressType 2 diabetes

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