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Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

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Updated: Jan 4, 2026

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

Neuronanotechnology for brain regeneration.

Kevin Liaw¹, Zhi Zhang², Sujatha Kannan²

¹Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, United States of America.

Advanced Drug Delivery Reviews

|November 1, 2019

Summary

This summary is machine-generated.

Nanotechnology offers new ways to stimulate neurogenesis after central nervous system (CNS) injury by targeting cellular and extracellular pathways. This approach aims to overcome limitations of current treatments for CNS regeneration.

Keywords:

Brain injury Extracellular matrix Nanotechnology Neurogenesis Regenerative medicine Targeted drug delivery

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Published on: June 13, 2017

Area of Science:

Neuroscience
Regenerative Medicine
Biotechnology

Background:

Central nervous system (CNS) regeneration is challenging due to complex cellular pathways and accessibility issues.
Current treatments for CNS injuries focus on mitigating damage rather than stimulating neurogenesis.
Regenerative medicine for CNS injuries has seen limited clinical success.

Purpose of the Study:

To review nanotechnology applications for CNS regeneration.
To organize these applications by cellular and extracellular targets.
To discuss future directions in the field.

Main Methods:

Literature review of nanotechnology in CNS regeneration.
Categorization of nanotechnology strategies based on biological targets.
Analysis of current challenges and future opportunities.

Main Results:

Nanotechnology enables fine-tuning of biological interactions for enhanced drug delivery.
Nanoscale features can stimulate cellular processes crucial for neurogenesis.
Applications are reviewed across various cellular and extracellular targets within the CNS.

Conclusions:

Nanotechnology presents a promising avenue for advancing CNS regeneration.
Targeting specific cellular and extracellular cues with nanomaterials can promote neurogenesis.
Further research and development are needed to translate these innovations into clinical practice.