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Updated: Jan 4, 2026
Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
Published on: July 14, 2023
Coronary artery disease is more severe in patients with primary hyperparathyroidism
Omar Koubaity1, Damien Mandry1, Phi-Linh Nguyen-Thi2
1Department of Radiology, University of Lorraine, CHU Nancy, Brabois Hospital, France.
Insights
Primary hyperparathyroidism patients show higher coronary calcification scores than controls. Age, mild hyperparathyroidism, and antihypertensive use predict elevated scores, suggesting new parathyroidectomy criteria.
Area of Science:
- Cardiology
- Endocrinology
- Public Health
Background:
- Primary hyperparathyroidism is linked to increased cardiovascular mortality.
- Mechanisms behind this association remain unclear.
- This study investigates coronary artery calcification in primary hyperparathyroidism.
Purpose of the Study:
- Evaluate coronary artery calcification using coronary calcification scores in primary hyperparathyroidism patients.
- Compare scores with a control group.
- Identify risk factors for high coronary calcification scores.
Main Methods:
- Cross-sectional study design.
- Included primary hyperparathyroidism patients without prior cardiovascular disease, diabetes, or severe kidney disease.
- Coronary calcification scores compared against population-based controls.
Main Results:
- Mean coronary calcification score was 120 ± 344 in 130 patients.
- 21% of patients had scores >100.
- Positive scores were higher in patients (53% vs 50%) and at the 67th percentile of controls (P < .001).
- Independent predictors for scores >100 included older age, mild normocalcemic primary hyperparathyroidism, and antihypertensive medication use.
Conclusions:
- Primary hyperparathyroidism patients exhibit greater coronary calcification than controls.
- Findings may inform parathyroidectomy criteria for primary hyperparathyroidism management.
Background:
Primary hyperparathyroidism is associated with an increased cardiovascular mortality, but mechanisms underlying this association are unclear. The goal of this study was to evaluate coronary artery calcifications via the coronary calcification score in primary hyperparathyroidism patients, to compare with control subjects, and to identify risk factors for high to intermediate risk coronary calcification scores (coronary calcification score >100).
Method:
Cross-sectional study of primary hyperparathyroidism patients without a history of coronary artery disease, diabetes, or severe, chronic kidney disease. Coronary calcification scores were compared with a cohort of population-based control subjects.
Results:
The mean coronary calcification score was 120 ± 344 in 130 primary hyperparathyroidism patients. The coronary calcification score was >100 in 27 patients (21%). When compared with control subjects, the percentage of positive coronary calcification scores was similar in primary hyperparathyroidism patients (53% vs 50%); however, positive coronary calcification scores were at the 67th percentile of the control subjects cohort (P < .001). In multivariable regression, patient age (1.1; 1.1-1.2; P < .001), patients in the mild normocalcemic primary hyperparathyroidism group (5.1; 1.1-22.6; P = .037), and the need for antihypertensive medications (6.1; 1.8-20.9; P < .001) remained independent predictors for a coronary calcification score >100.
Conclusion:
Positive coronary calcification scores were greater in primary hyperparathyroidism patients than in population-based control subjects. These study data may provide new criteria for parathyroidectomy in patients with primary hyperparathyroidism.
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