Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

8.4K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
8.4K
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

4.6K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
4.6K
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

8.0K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
8.0K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

796
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
796
Lipid-derived Compounds in the Human Body01:31

Lipid-derived Compounds in the Human Body

6.1K
Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
Fat-soluble Vitamins
Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin,...
6.1K
Erythropoiesis01:14

Erythropoiesis

5.6K
Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia,...
5.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Baseline serum metabolites predict fractures in individuals who were Black and had type 2 diabetes.

Frontiers in endocrinology·2026
Same author

The periosteum as an endocrine organ: historical foundations and new insights.

Open biology·2026
Same author

Bone as an endocrine regulator of lipid and energy metabolism.

Reviews in endocrine & metabolic disorders·2026
Same author

11β-Hydroxysteroid dehydrogenase type 1 deficiency causes sexual dimorphism in body composition and bone mass in response to caloric restriction.

JBMR plus·2026
Same author

Neuroendocrine and neural control of bone mass in health and disease.

The Journal of clinical investigation·2026
Same author

Intact mTOR signaling in gastric X/A-like cells is required for bone homeostasis.

Frontiers in endocrinology·2026
Same journal

AARS1 promotes tumor progression and immune evasion via ATF6 lactylation-mediated tryptophan metabolism in hepatocellular carcinoma.

Cell metabolism·2026
Same journal

Reactive species as regulators of immune cell metabolism, tolerance, and autoimmunity.

Cell metabolism·2026
Same journal

The interplay between the microbiome and immune cells in metabolic homeostasis and disease.

Cell metabolism·2026
Same journal

The metabolic basis of regulated cell death.

Cell metabolism·2026
Same journal

Gut microbiota-derived lysine phenylacetylation impairs mitochondrial function and is alleviated by SIRT3.

Cell metabolism·2026
Same journal

Methionine-supplemented longevity diet increases growth hormone, GLP-1, and FGF21; reduces frailty; and promotes healthspan.

Cell metabolism·2026
See all related articles

Related Experiment Video

Updated: Jan 4, 2026

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts
09:07

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts

Published on: December 16, 2022

3.7K

Lipids in the Bone Marrow: An Evolving Perspective.

Elizabeth Rendina-Ruedy1, Clifford J Rosen2

  • 1Center for Molecular Medicine, Research Institute, Maine Medical Center, Scarborough, ME 04074, USA; Vanderbilt Center for Bone Biology, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA; Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Cell Metabolism
|November 1, 2019
PubMed
Summary
This summary is machine-generated.

Marrow lipids, contrary to previous beliefs, are essential for bone health. This study reviews evidence on how bone marrow fat supports skeletal homeostasis and function.

Keywords:
adipocytesbonecholesteroldietenergyfatosteoblasts

More Related Videos

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
06:33

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Published on: November 10, 2023

1.7K
Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone
09:31

Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone

Published on: April 8, 2015

11.9K

Related Experiment Videos

Last Updated: Jan 4, 2026

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts
09:07

A Human Bone Marrow 3D Model to Investigate the Dynamics and Interactions Between Resident Cells in Physiological or Tumoral Contexts

Published on: December 16, 2022

3.7K
Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies
06:33

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Published on: November 10, 2023

1.7K
Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone
09:31

Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone

Published on: April 8, 2015

11.9K

Area of Science:

  • Bone Biology
  • Metabolism
  • Cellular Physiology

Background:

  • The skeletal system's high energy demands necessitate close links with whole-body metabolism.
  • Bone remodeling relies on fuel sources like glucose, amino acids, and fatty acids.
  • Bone marrow adipocytes, previously considered mere "filler," are now investigated for their metabolic role.

Purpose of the Study:

  • To challenge the notion that bone marrow adipocytes are detrimental to skeletal homeostasis.
  • To propose that lipids stored in bone marrow are essential for proper bone functioning.
  • To review current evidence on lipid metabolism within the skeletal niche.

Main Methods:

  • Examination of existing scientific literature.
  • Inclusion of data from both in vitro and in vivo model systems.
  • Analysis of lipid storage, utilization, and export in the bone marrow.

Main Results:

  • Lipids mobilized from bone marrow can serve as a potent source of fatty acids for bone cells.
  • Evidence suggests a crucial role for marrow lipids in supporting skeletal homeostasis.
  • The study highlights the complex interplay between lipid turnover and bone health.

Conclusions:

  • Bone marrow lipids are integral to skeletal homeostasis, not detrimental.
  • Further research is needed to fully understand the relationship between lipid turnover and bone health.
  • Adipocytes in bone marrow play a vital metabolic role in bone maintenance and function.