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Energy Trade-offs in Host Defense: Immunology Meets Physiology
Alexandre A Steiner1, Andrej A Romanovsky2
1Neuroimmunology of Sepsis Laboratory, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP 05508, Brazil.
Abstract:
Host defense relies not only on microbicidal mechanisms (resistance), but also on management of collateral damage (tolerance). Here, we discuss how this immunology concept converges with a physiology-born theory on the dichotomy of thermometabolic responses in infection (fever versus hypothermia), yielding a model of immunity that transcends discipline barriers.
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