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Updated: Jan 4, 2026

Author Spotlight: Two-Step Tag-Free Isolation of Mitochondria for Improved Protein Discovery and Quantification
Published on: June 2, 2023
The basic machineries for mitochondrial protein quality control
Carmela Vazquez-Calvo1, Tamara Suhm2, Sabrina Büttner3
1Department of Biochemistry and Biophysics, Stockholm University, Svante Arrheniusväg 16, Stockholm 106 91, Sweden; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Svante Arrheniusväg 20C, Stockholm 106 91, Sweden.
Abstract:
Mitochondria play pivotal roles in cellular energy metabolism, the synthesis of essential biomolecules and the regulation of cell death and aging. The proper folding, unfolding and degradation of the many proteins active within mitochondria is surveyed by the mitochondrial quality control machineries. Here, we describe the principal components of the mitochondrial quality control system and recent developments in the elucidation of the molecular mechanisms maintaining a functional mitochondrial proteome.
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