The ecology and evolution of microbial metabolic strategies

Free-living microbes are generally capable of growing on multiple different nutrients. Some of those nutrients are used simultaneously, while others are used sequentially. The pattern of nutrient preferences and co-utilization defines the metabolic strategy of a microorganism. Metabolic strategies can substantially affect ecological interactions between species, but their evolution and distribution across the tree of life remain poorly characterized. We discuss how the confluence of better computational models of genotype-phenotype maps and high-throughput experimental tools can help us fill gaps in our knowledge and incorporate metabolic strategies into quantitative predictive models of microbial consortia.