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Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
Published on: March 1, 2024
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Homocysteine and psoriasis.
Xiran Lin1, Xianmin Meng2, Zhiqi Song1
1Department of Dermatology, the First Affiliated Hospital of Dalian Medical University. 222 Zhongshan Lu, Dalian 116011, China.
Bioscience Reports
|November 1, 2019
Summary
Elevated homocysteine (Hcy) levels are linked to psoriasis pathogenesis by promoting inflammation. Supplementing folic acid and vitamin B12 may offer therapeutic benefits for psoriasis patients.
Area of Science:
- Dermatology
- Immunology
- Biochemistry
Background:
- Psoriasis involves immune, genetic, and environmental factors.
- Psoriasis patients exhibit higher serum homocysteine (Hcy) and hyperhomocysteinemia (HHcy) prevalence.
- Folic acid and vitamin B12 insufficiency can cause HHcy in psoriasis.
Purpose of the Study:
- To investigate the role of homocysteine (Hcy) in psoriasis pathogenesis.
- To explore the potential of Hcy as a therapeutic target for psoriasis.
- To examine the impact of HHcy on immuno-inflammatory processes in psoriasis.
Main Methods:
- Analysis of serum homocysteine (Hcy) levels in psoriasis patients.
- Review of studies on the immuno-inflammatory effects of Hcy.
- Evaluation of the therapeutic efficacy of folic acid and vitamin B12 supplementation.
Main Results:
- Hcy promotes psoriasis immuno-inflammation by activating Th1/Th17 cells and neutrophils, suppressing regulatory T cells.
- Hcy enhances pro-inflammatory cytokine production and nuclear factor kappa B activation.
- HHcy may be linked to oxidative stress and reduced hydrogen sulfide (H2S) levels in psoriasis.
Conclusions:
- Homocysteine (Hcy) plays a significant role in psoriasis pathogenesis and is a potential therapeutic target.
- Systemic folinate calcium and topical vitamin B12 show effectiveness in treating psoriasis.
- Addressing HHcy through supplementation may be a viable strategy for psoriasis management.
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