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Related Experiment Videos

The post-aspirin bleeding time: a screening test for evaluating haemostatic disorders.

M J Stuart, M L Miller, F R Davey

    British Journal of Haematology
    |December 1, 1979
    PubMed
    Summary

    The aspirin tolerance test significantly improves bleeding time screening for hemostasis disorders. This test enhances the detection of conditions like von Willebrand

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    Area of Science:

    • Hematology
    • Clinical Diagnostics

    Background:

    • Bleeding time (B.T.) is a standard hemostasis test.
    • Aspirin ingestion can affect bleeding time.
    • Sensitivity of B.T. alone for detecting hemostatic disorders is limited.

    Purpose of the Study:

    • To evaluate the diagnostic utility of template bleeding time post-aspirin ingestion.
    • To assess the aspirin tolerance test's effectiveness in screening for hemostatic abnormalities.

    Main Methods:

    • Template bleeding time was measured in 28 controls and 71 patients.
    • Tests included initial bleeding time and bleeding time after 600 mg aspirin ingestion.
    • Patients with abnormal results were further evaluated for von Willebrand's disease and platelet dysfunction.

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    Main Results:

    • Aspirin ingestion prolonged mean bleeding time from 3.5 to 6.3 minutes.
    • The aspirin tolerance test identified abnormalities in patients with initially normal bleeding times.
    • Overall sensitivity for detecting hemostatic abnormalities increased from 40% to 94% with the aspirin tolerance test.

    Conclusions:

    • The aspirin tolerance test significantly enhances the sensitivity of bleeding time as a screening tool for hemostatic disorders.
    • This test is particularly useful for identifying asymptomatic von Willebrand's disease and platelet dysfunction.
    • Incorporating the aspirin tolerance test improves the detection rate of hemostatic abnormalities in patient populations.