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Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

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Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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Coronary Artery Disease III: Clinical Manifestations01:30

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Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
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Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
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Coronary Artery Disease II: Pathophysiology01:26

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Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Related Experiment Video

Updated: Jan 4, 2026

Evaluation of a Novel Laser-assisted Coronary Anastomotic Connector - the Trinity Clip - in a Porcine Off-pump Bypass Model
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Type 3 Coronary Perforation on Optical Coherence Imaging.

Viji S Thomson1, Lijo Varghese, George Joseph

  • 1Dept. of Cardiology, Christian Medical College and Hospital, Vellore, India 632 004. vijisamuel1970@gmail.com.

The Journal of Invasive Cardiology
|November 1, 2019
PubMed
Summary
This summary is machine-generated.

Optical coherence tomography (OCT) identified a transmural arterial breach. Focal negative remodeling, not plaque, was the cause of this coronary rupture.

Keywords:
Dragonfly imaging cathetercardiac imagingoptical coherence tomography

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Area of Science:

  • Cardiovascular imaging
  • Interventional cardiology
  • Arterial pathophysiology

Background:

  • Coronary artery rupture is a rare but serious complication during percutaneous coronary interventions.
  • The underlying mechanisms leading to rupture in the absence of significant plaque burden remain poorly understood.

Observation:

  • Optical coherence tomography (OCT) imaging was utilized to investigate a case of unexplained coronary rupture.
  • A 1.5 mm transmural breach was identified in an arterial segment lacking calcium or eccentric plaque.

Findings:

  • The arterial breach was associated with focal negative remodeling.
  • Negative remodeling, rather than plaque characteristics, was identified as the primary cause of the coronary rupture.

Implications:

  • This finding suggests that negative arterial remodeling can predispose to rupture, even in non-culprit segments.
  • OCT imaging is crucial for identifying subtle structural changes that may lead to procedural complications.
  • Understanding these mechanisms can help refine interventional strategies and improve patient safety.