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Updated: Jan 4, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
A case of idiosyncratic liver injury after oxaliplatin-induced thrombocytopenia
Shinji Honda1, Masayuki Tsujimoto2, Tetsuya Minegaki2
1Department of Pharmacy, Kyoto City Hospital, Kyoto, Japan.
What Is Known And Objective:
Oxaliplatin is a platinum drug used for treating digestive cancers that can lead to drug-induced thrombocytopenia (DITP). We report a case of oxaliplatin-induced anaphylaxis and DITP, complicated by idiosyncratic drug-induced liver injury (IDILI).
Case Summary:
A 46-year-old woman with rectal cancer developed anaphylaxis shortly after oxaliplatin administration (post-operative CapeOX), presenting with low platelet count (0.2 × 104 /µL) and elevated aspartate aminotransferase (1091 IU/L) and alanine aminotransferase (1010 IU/L) by day 10. Following 50 mg/d prednisolone administration from day 9, she left the hospital on day 36 after recovering.
What Is New And Conclusion:
This is the first case report of oxaliplatin-induced IDILI and its effective treatment with steroids.
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