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Updated: Jan 4, 2026
03:55
Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer
Published on: June 9, 2023
901
Treatment of Differentiated Thyroid Carcinomas
Melissa G Lechner1, Stephanie Smooke Praw2, Trevor E Angell3
1Division of Endocrinology, Diabetes, and Metabolism, David Geffen School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, CHS 57-145, Los Angeles, CA 90095, USA.
Surgical Pathology Clinics
|November 2, 2019
Summary
Differentiated thyroid cancer (DTC) incidence is rising. Treatment options include surgery, radioactive iodine (RAI), and levothyroxine, with active surveillance for low-risk cases and novel agents for metastatic disease.
Area of Science:
- Oncology
- Endocrinology
Background:
- Differentiated thyroid cancer (DTC) is the most common endocrine malignancy.
- Significant increase in DTC incidence over the past 30 years.
- Standard treatments include surgery, radioactive iodine (RAI), and levothyroxine suppression therapy.
Purpose of the Study:
- To review current management strategies for differentiated thyroid cancer.
- To discuss the role of active surveillance and novel therapeutic agents.
Main Methods:
- Literature review of clinical practice guidelines and recent studies.
- Analysis of treatment modalities based on patient characteristics and disease stage.
Main Results:
- Active surveillance is a viable option for selected low-risk DTC patients.
- Patient factors significantly impact treatment choice and intensity.
- For progressive metastatic DTC unresponsive to surgery or RAI, targeted therapies and immunotherapy are emerging options.
Conclusions:
- Treatment for DTC requires individualized approaches.
- Novel agents offer new hope for patients with advanced or refractory metastatic disease.
Keywords:
Active surveillanceBRAFDifferentiated thyroid cancerDynamic risk stratificationRadioactive iodineSurgeryTreatmentTyrosine kinase inhibitorMore Related Videos
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