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Non-cystic fibrosis bronchiectasis in children and adolescents: Neglected and emerging issues

Marco Poeta1, Marco Maglione1, Melissa Borrelli1

  • 1Department of Translational Medical Sciences, Section of Pediatrics, Federico II University, Naples, Italy.

Pediatrics and Neonatology
|November 2, 2019
PubMed

Insights

Pediatric non-cystic fibrosis (CF) bronchiectasis management is reviewed, focusing on novel assessment techniques and treatment advances. A new diagnostic algorithm is proposed to aid clinicians in managing this complex pediatric lung disease.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Medicine

Background:

  • Pediatric non-cystic fibrosis (CF) bronchiectasis presents with airway inflammation and mucus issues, often leading to recurrent infections and cough.
  • Current management guidelines largely rely on expert opinion or extrapolation from CF practices.
  • There is a need for evidence-based strategies tailored to non-CF bronchiectasis in children.

Purpose of the Study:

  • To review current knowledge and address open questions in managing pediatric non-CF bronchiectasis.
  • To explore the role of technological advancements in lung disease assessment.
  • To summarize recent developments in disease prevention and treatment, and propose a diagnostic algorithm.

Main Methods:

  • Narrative review of existing literature.
  • Analysis of novel chest imaging techniques and pulmonary function tests.
  • Synthesis of information on disease prevention, treatment, and diagnostic approaches.

Main Results:

  • Technological advances offer new possibilities for assessing lung disease in pediatric non-CF bronchiectasis.
  • Novelties in prevention and treatment strategies are emerging.
  • A proposed diagnostic algorithm can assist physicians in clinical decision-making.

Conclusions:

  • Further research with larger cohorts and longer trials is crucial.
  • Identifying new clinical and laboratory endpoints is needed to understand disease progression.
  • Evidence-based management strategies are essential for improving outcomes in pediatric non-CF bronchiectasis.

Keywords:
adolescentsbronchiectasischildrenchronic coughsuppurative lung disease

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