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Updated: Jan 4, 2026

Frailty Assessment in an Aging Mouse Model
Published on: September 23, 2025
Development of a Frailty Phenotype Questionnaire for Use in Screening Community-Dwelling Older Adults
Sunyoung Kim1, Miji Kim2, Hee-Won Jung3
1Department of Family Medicine, Kyung Hee University Medical Center, Seoul, Republic of Korea.
Objective:
The purpose of this study was to develop a screening questionnaire for frailty based on the Fried frailty phenotype (FFP) in community-dwelling older adults.
Design:
Cross-sectional data analysis of a cohort study.
Setting And Participants:
The study used baseline data from the Korean Frailty and Aging Cohort Survey, a multicenter longitudinal study undertaken in 10 urban, rural, and suburban communities in Korea between 2016 and 2017. A total of 2917 older adults aged 70 to 84 years were included in the analysis, who were administered questionnaires and physical function tests.
Methods:
Gait speed and grip strength were measured, and all participants completed the International Physical Activity Questionnaire and answered questions about weight loss and exhaustion based on FFP.
Results:
Five questions were chosen to screen for FFP: fatigue (exhaustion), resistance (weakness), ambulation (slowness), inactivity, and loss of weight. The Frailty Phenotype Questionnaire (FPQ; range of 0-5) was well correlated with the Fried frailty scale (range of 0-5) (r = 0.643; P < .001). Frailty based on the FPQ score (≥3 of 5) showed satisfactory diagnostic accuracy for FFP (area under the curve = 0.89), with high sensitivity (81.7%) and specificity (82.5%).
Conclusions And Implications:
The FPQ is a highly accurate screening tool for FFP in community-dwelling older adults.
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