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Four-dimensional bioprinting: Current developments and applications in bone tissue engineering.

Zhuqing Wan1, Ping Zhang1, Yunsong Liu1

  • 1Department of Prosthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, National Clinical Research Center for Oral Diseases, Beijing Key Laboratory of Digital Stomatology, 22 Zhongguancun Avenue South, Haidian District, Beijing 100081, PR China.

Acta Biomaterialia
|November 2, 2019
PubMed
Summary

Four-dimensional (4D) bioprinting integrates time into 3D bioprinting for advanced tissue engineering. This technology enables the creation of dynamic, shape-changing biological structures, offering significant potential for bone tissue repair and regeneration.

Keywords:
3D bioprinting4D bioprintingBone regenerationShape memory hydrogelsShape memory polymersTissue engineering

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Area of Science:

  • Biomedical Engineering
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Four-dimensional (4D) bioprinting extends three-dimensional (3D) bioprinting by incorporating time as a fourth dimension.
  • It enables the fabrication of dynamic biological structures that can change shape or function in response to stimuli.
  • This technology holds significant promise for tissue engineering, particularly for bone regeneration.

Purpose of the Study:

  • To review the application of stimuli-responsive biomaterials in 4D bioprinting for tissue engineering.
  • To discuss various 4D bioprinting strategies based on functional transformation.
  • To highlight the potential of 4D bioprinting in bone tissue engineering, including challenges and future outlook.

Main Methods:

  • Review of existing literature on 4D bioprinting technologies and stimuli-responsive materials.
  • Analysis of strategies for fabricating dynamic, cell-laden constructs.
  • Examination of applications in bone tissue engineering, focusing on shape memory and functional maturation.

Main Results:

  • 4D bioprinting utilizes stimuli-responsive materials to create 3D-patterned biological architectures with dynamic capabilities.
  • Functional transformation and maturation of printed constructs over time are key aspects of 4D bioprinting.
  • Shape memory properties and osteogenic differentiation promotion are crucial for bone defect repair.

Conclusions:

  • 4D bioprinting represents a next-generation solution in tissue engineering, enabling complex and functional biological structures.
  • The technology offers unprecedented potential for personalized bone defect repair and promoting stem cell differentiation.
  • Addressing current challenges will pave the way for widespread biomedical applications of 4D bioprinting.