Related Experiment Video
Updated: Jan 4, 2026
08:00
Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
Published on: May 26, 2021
13.8K
Clonal hematopoiesis in human aging and disease
Siddhartha Jaiswal1, Benjamin L Ebert2,3
1Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA. sjaiswal@stanford.edu benjamin_ebert@dfci.harvard.edu.
Science (New York, N.Y.)
|November 2, 2019
Summary
Aging tissues accumulate somatic mutations, sometimes leading to advantageous cell growth called clonal hematopoiesis. This prevalent condition in the elderly links to aging diseases and immune function, offering insights into mutation and selection.
Area of Science:
- Gerontology
- Genetics
- Immunology
Background:
- Somatic mutations accumulate with age in human tissues.
- A subset of mutations confers a cellular fitness advantage.
- This can lead to clonal expansion, particularly in the hematopoietic system.
Purpose of the Study:
- To review recent advances in understanding clonal hematopoiesis.
- To explore its connections to aging-related diseases and malignancies.
- To discuss its impact on immune function.
Main Methods:
- Literature review of recent research on clonal hematopoiesis.
- Analysis of the relationship between clonal hematopoiesis and age-related conditions.
- Examination of the immunological consequences of clonal hematopoiesis.
Main Results:
- Clonal hematopoiesis is highly prevalent in the elderly.
- It is associated with an increased risk of hematologic malignancies.
- It is linked to nonmalignant diseases of aging and altered immune function.
Conclusions:
- Clonal hematopoiesis is a significant hallmark of aging.
- It provides a model for studying somatic mutation and selection in vivo.
- Understanding clonal hematopoiesis is crucial for managing age-related diseases and immune decline.
Related Concept Videos
01:21Hematopoiesis
8.4K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
8.4K
01:20Overview of Hematopoiesis
8.0K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
8.0K
01:01Regulation of Hematopoietic Stem Cells
3.8K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.8K
01:19Multipotency of Hematopoietic Stem Cells
3.7K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.7K
01:19The Effect of Aging on Tissues
3.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.1K
01:26Aging
545
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
545