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Mephentermine dependence with psychosis. A case report
1Department of Psychiatry, Kasturba Medical College Hospital, Manipal, India.
Summary
Mephentermine dependence, though unreported, can sustain chronic psychosis. This case highlights psychosis relapse with mephentermine abuse after remission, emphasizing its potential for psychiatric harm.
Area of Science:
- Psychiatry
- Pharmacology
- Neuroscience
Background:
- Mephentermine is a sympathomimetic amine used as a pressor agent.
- Inhaler misuse is a known issue, but mephentermine dependence is unreported.
- Chronic psychosis can be associated with substance abuse.
Observation:
- A case study details mephentermine dependence in a patient with chronic psychosis.
- The patient's psychosis initially emerged with dexamphetamine abuse.
- Mephentermine sustained the psychosis for three years.
Findings:
- Following a four-year remission, the patient relapsed into psychosis upon restarting mephentermine abuse.
- This relapse persisted for five years, indicating a potential for sustained psychiatric disturbance.
- The findings suggest mephentermine can induce or exacerbate psychosis.
Implications:
- This case highlights the potential for mephentermine dependence and its association with chronic psychosis.
- It underscores the need for vigilance regarding sympathomimetic amine abuse in psychiatric patients.
- Further research is warranted to understand the neurobiological mechanisms underlying mephentermine-induced psychosis.