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Published on: June 21, 2021
Electrochemical oxidation induced selective tyrosine bioconjugation for the modification of biomolecules
Chunlan Song1, Kun Liu1, Zhongjie Wang1
1College of Chemistry and Molecular Sciences , Institute for Advanced Studies (IAS) , Wuhan University , Wuhan 430072 , P. R. China .
Abstract:
Directly introducing a beneficial functional group into biomolecules under mild, clean and easy-to-handle conditions is of great importance in the field of chemical biology and pharmacology. Herein, we described an electrochemical strategy to perform the bioconjugation of tyrosine residues with phenothiazine derivatives in a rapid and simple manner. In this electrochemical system, various polypeptides and proteins were successfully labelled with excellent site- and chemo-selectivity, and metals, oxidants or additives were also avoided.
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