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Metformin Intoxication with Severe Renal Damage: An Adolescent Case Report
Ahmet Yontem1, Nagehan Aslan1, Ozden Ozgur Horoz1
1Division of Pediatric Intensive Care Unit, Faculty of Medicine, Çukurova University, Adana, Turkey.
Journal of Pediatric Intensive Care
|November 2, 2019
Summary
Metformin overdose can cause dangerous lactic acidosis. Early kidney support is crucial for recovery, as shown in a teen suicide attempt case.
Area of Science:
- Endocrinology
- Nephrology
- Toxicology
Background:
- Metformin, a biguanide oral antidiabetic drug, is widely used but carries a risk of lactic acidosis.
- Metformin-associated lactic acidosis (MALA) is a serious, potentially fatal complication requiring prompt management.
Observation:
- A 16-year-old patient attempted suicide by ingesting metformin, leading to severe lactic acidosis.
- The patient developed significant renal damage during the course of treatment.
Findings:
- Continuous renal replacement therapy (CRRT) was initiated for metformin intoxication and lactic acidosis.
- Early CRRT played a vital role in managing the patient's critical condition and preventing further complications.
Implications:
- This case highlights the critical importance of timely and aggressive renal replacement therapy in MALA.
- Prompt intervention with CRRT can mitigate severe outcomes and improve survival rates in metformin poisoning.
- Emphasizes the need for vigilant monitoring for renal complications in patients with MALA.
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