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Updated: Jan 4, 2026

Multimodal Imaging and Spectroscopy Fiber-bundle Microendoscopy Platform for Non-invasive, In Vivo Tissue Analysis

Multimodal Imaging and Spectroscopy Fiber-bundle Microendoscopy Platform for Non-invasive, In Vivo Tissue Analysis

Published on: October 17, 2016

Advanced multispectral image-processing endoscopy system for visualizing two-dimensional hemoglobin saturation and

Toru Chiba¹, Yoshimi Obara¹, Masaharu Murata²

¹Pentax Life Care Division, Hoya Corporation, Tokyo, Japan.

Endoscopy International Open

|November 2, 2019

Summary

This summary is machine-generated.

This study developed a multispectral endoscopy system to map hemoglobin (Hb) concentration and saturation. This tool aids in detecting tumors in vivo by visualizing oxygenation differences in tissues.

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Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function

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Last Updated: Jan 4, 2026

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Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function

Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function

Published on: December 8, 2010

Area of Science:

Biomedical optics
Medical imaging
Cancer detection

Background:

Tumor hypoxia and vascularization are linked to malignant progression.
Measuring tissue hemoglobin (Hb) saturation and concentration is a key diagnostic approach.
In vivo detection of these parameters remains challenging.

Purpose of the Study:

To design a simple algorithm and multispectral image-processing endoscopy system.
To map relative Hb concentration and Hb saturation for in vivo tumor detection in small animal viscera.
To validate the system for real-time video examination.

Main Methods:

Developed a simplified spectral data capture and analysis method for diffuse mucosal reflection.
Designed an optical filter-equipped endoscope for 2D visualization of Hb concentration and saturation maps.
Validated the system using a small animal model.

Main Results:

Obtained an Hb saturation calibration curve.
Successfully determined differences in oxygenation levels between normal mucosa and in vivo tumors.
Achieved a mapping frame rate comparable to white light imaging (7.5 fps).

Conclusions:

A novel multispectral image-processing endoscopic system was developed.
The system enables in vivo mapping of Hb concentration and saturation for tumor detection.
The system offers real-time visualization with high frame rates.