Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trends in brachytherapy utilization in Canada from 2011 to 2020.

Physics and imaging in radiation oncology·2026
Same author

Mediation analysis of adherence to pelvic floor muscle training and weekly self-monitoring on urinary symptoms in men with localized prostate cancer: A secondary analysis of the Prostate Cancer-Patient Empowerment Program (PC-PEP) randomized controlled trial.

Canadian Urological Association journal = Journal de l'Association des urologues du Canada·2026
Same author

Competency-Based Simulation and Evaluation in Medical Education: Clinical Decision Making and Reference Dosimetry.

International journal of radiation oncology, biology, physics·2026
Same author

Radiation Effects in Electret Organic Thin-Film Transistors Due to High Flux and High Dose X-Ray Irradiation.

Advanced materials (Deerfield Beach, Fla.)·2025
Same author

HyperSight CBCT image quality and metal artifact reduction for adaptive head and neck radiotherapy: Results from a prospective clinical trial.

Journal of applied clinical medical physics·2025
Same author

Understanding Equity, Diversity, and Inclusion Within Canadian Radiation Oncology Training Programs: A National Survey of Residents and Fellows.

Current oncology (Toronto, Ont.)·2025

Related Experiment Video

Updated: Jan 4, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.9K

Individualized Dose-Escalation of HDR Prostate Brachytherapy Implant to Decrease Required External Beam Radiation

Hannah M Dahn1, Patricia A K Oliver2, Stefan Allen1

  • 1Department of Radiation Oncology, Dalhousie University, Halifax, NS, Canada.

Advances in Radiation Oncology
|November 2, 2019
PubMed
Summary
This summary is machine-generated.

Individualized high-dose-rate brachytherapy (HDR-BT) dose escalation to 16 or 17 Gy is feasible for localized prostate cancer. This approach may reduce external beam radiation therapy (EBRT) fractions, improving patient convenience and treatment tolerance.

More Related Videos

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

3.1K
Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

16.1K

Related Experiment Videos

Last Updated: Jan 4, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.9K
Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

3.1K
Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

16.1K

Area of Science:

  • Radiation oncology
  • Medical physics

Background:

  • High-dose-rate brachytherapy (HDR-BT) combined with external beam radiation therapy (EBRT) is a standard treatment for localized prostate cancer.
  • Personalized dose escalation aims to reduce EBRT while maintaining treatment efficacy.

Purpose of the Study:

  • To assess the dosimetric feasibility of escalating HDR-BT dose to 16 or 17 Gy.
  • To determine if organ-at-risk (OAR) constraints from a 15 Gy plan can be met with escalated doses on an individualized basis.

Main Methods:

  • Retrospective analysis of 53 HDR-BT plans.
  • Reoptimization of plans to deliver 16 Gy or 17 Gy while adhering to 15 Gy OAR constraints.
  • Examination of factors associated with successful dose escalation.

Main Results:

  • 74% of plans (39/53) were successfully escalated to 16 Gy.
  • 4% of plans (2/53) were successfully escalated to 17 Gy.
  • Rectal V80 and urethral Dmax were predictive of successful 16 Gy dose escalation.

Conclusions:

  • Individualized HDR-BT dose escalation beyond 15 Gy is dosimetrically feasible within OAR constraints.
  • This strategy allows for EBRT dose reduction, potentially improving patient tolerance and resource efficiency.
  • A clinical trial is planned to evaluate the efficacy and safety of personalized HDR-BT/EBRT fractionation.