Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental smallpox in chimpanzees.

S S Kalter, A R Rodríguez, L B Cummins

    Bulletin of the World Health Organization
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Comparison of umbilical artery pulsatility index reference ranges.

    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2025
    Same author

    Conditioning of desert sandy soil and investigation of the ameliorative effects of poultry manure and bentonite treatment rate on plant growth.

    Brazilian journal of biology = Revista brasleira de biologia·2023
    Same author

    Robotic-Assisted Partial Nephrectomy: Techniques to Improve Clinical Outcomes.

    Current urology reports·2021
    Same author

    [Ischemia is not an independent predictive factor of chronic renal failure after partial nephrectomy in a solitary kidney in patients without pre-operative renal insufficiency].

    Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2014
    Same author

    Predictive factors of chronic kidney disease stage V after partial nephrectomy in a solitary kidney: a multi-institutional study.

    Urologic oncology·2013
    Same author

    Screening test to detect meat adulteration through the determination of hemoglobin by cation exchange chromatography with diode array detection.

    Meat science·2011
    Same journal

    Diplomatic roles of regional coordinators for WHO Member States.

    Bulletin of the World Health Organization·2026
    Same journal

    Evaluation of an application for investments in cataract surgery, Ethiopia.

    Bulletin of the World Health Organization·2026
    Same journal

    An umbrella protocol for the clinical evaluation of diagnostics in infectious disease.

    Bulletin of the World Health Organization·2026
    Same journal

    Fundamental changes in regulation to improve access to biosimilars.

    Bulletin of the World Health Organization·2026
    Same journal

    A public-private partnership for facility-based tuberculosis screening using chest radiographs, Viet Nam.

    Bulletin of the World Health Organization·2026
    Same journal

    Ebola at a critical juncture: preparedness must outpace transmission.

    Bulletin of the World Health Organization·2026
    See all related articles

    Highly specific antiserum preparation for variola virus in chimpanzees led to unexpected cross-reactivity. Infected animals developed antibodies to vaccinia and monkeypox viruses, with no human transmission observed.

    Area of Science:

    • Virology
    • Immunology
    • Primate Research

    Background:

    • Variola virus, the causative agent of smallpox, poses a significant biosecurity risk.
    • Developing specific antiserum is crucial for diagnostic and therapeutic applications.
    • Chimpanzees are utilized as models for studying viral pathogenesis and immune responses.

    Purpose of the Study:

    • To generate highly specific antiserum against variola virus.
    • To investigate the immune response in chimpanzees inoculated with variola virus.
    • To assess potential cross-reactivity with related orthopoxviruses.

    Main Methods:

    • Inoculation of one chimpanzee with a virulent human strain of variola virus.
    • Housing of three uninoculated chimpanzees in the same room for exposure assessment.

    Related Experiment Videos

  • Serological testing for antibodies against variola, vaccinia, and monkeypox viruses.
  • Clinical monitoring of all animals for signs of disease.

    • Main Results:

    • Two of three in-contact chimpanzees developed clinical disease and seroconverted.
    • One in-contact chimpanzee showed no signs of infection or antibody development.
    • All three ill animals developed antibodies to both vaccinia and monkeypox viruses, indicating cross-reactivity.

    Conclusions:

    • Inoculation with variola virus can induce cross-reactive antibodies to vaccinia and monkeypox viruses in chimpanzees.
    • The study highlights challenges in preparing highly specific variola virus antiserum due to cross-reactivity.
    • No evidence of infection or disease was observed in human contacts, suggesting limited zoonotic potential under these conditions.