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Updated: Jan 4, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Perovskanol, a new sesquiterpenoid with an unprecedented skeleton from Perovskia Abrotanoides
Seyedeh Masoomeh Karimzadeh1, Mahdi Moridi Farimani1, Mohammad Sadegh Amiri2
1Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G. C, Evin, Tehran, Iran.
Abstract:
Phytochemical investigation of the aerial parts of Perovskia abrotanoides (Lamiaceae) by normal phase column chromatography resulted in the isolation of perovskanol (1), a novel sesquiterpenoid possessing a 5/7/5 fused carbon ring skeleton. The structure of 1 was established by comprehensive spectroscopic data analysis including 1 D and 2 D NMR and HRESIMS. The antiprotozoal activity of compound 1 was evaluated against Trypanosoma brucei rhodesiense, T. cruzi, Leishmania donovani, Plasmodium falciparum and no promising activities were shown against all parasite tested.
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