Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Temporal 2G-5G RF-EMF exposure assessment in ten European countries during one year.

The Science of the total environment·2026
Same author

Prediction of cardiac cycle duration for cardiac-gated closed-loop auricular vagus nerve stimulation.

Frontiers in neuroscience·2026
Same author

Radon balneotherapy in rheumatologic diseases: potential mechanisms and implications for cardiovascular autonomic control and inflammation.

Clinical rheumatology·2026
Same author

Correction: Sustained blood pressure reduction associated with percutaneous auricular vagus nerve stimulation in hypertensive chronic pain patients: a retrospective dual-center analysis.

Frontiers in cardiovascular medicine·2026
Same author

Generic neural network model for estimating exposure levels in industrial environments.

Journal of radiological protection : official journal of the Society for Radiological Protection·2026
Same author

Sustained blood pressure reduction associated with percutaneous auricular vagus nerve stimulation in hypertensive chronic pain patients: a retrospective dual-center analysis.

Frontiers in cardiovascular medicine·2026

Related Experiment Video

Updated: Jan 4, 2026

Author Spotlight: Exploring the Effects of Transauricular Vagus Nerve Stimulation
04:59

Author Spotlight: Exploring the Effects of Transauricular Vagus Nerve Stimulation

Published on: January 19, 2024

3.5K

Stimulation Pattern Efficiency in Percutaneous Auricular Vagus Nerve Stimulation: Experimental Versus Numerical Data.

Eugenijus Kaniusas, Amine Mohammed Samoudi, Stefan Kampusch

    IEEE Transactions on Bio-Medical Engineering
    |November 2, 2019
    PubMed
    Summary

    Triphasic stimulation (TS) is more effective than biphasic (BS) and monophasic (MS) stimulation for auricular vagus nerve (pVNS) electrical stimulation. This optimized approach moves beyond empirical settings for efficient pVNS therapy.

    More Related Videos

    Laboratory Administration of Transcutaneous Auricular Vagus Nerve Stimulation taVNS: Technique, Targeting, and Considerations
    06:31

    Laboratory Administration of Transcutaneous Auricular Vagus Nerve Stimulation taVNS: Technique, Targeting, and Considerations

    Published on: January 7, 2019

    41.1K
    Transauricular Vagus Nerve Stimulation and Electroencephalographic Assessment in Disorders of Consciousness
    04:04

    Transauricular Vagus Nerve Stimulation and Electroencephalographic Assessment in Disorders of Consciousness

    Published on: July 11, 2025

    1.2K

    Related Experiment Videos

    Last Updated: Jan 4, 2026

    Author Spotlight: Exploring the Effects of Transauricular Vagus Nerve Stimulation
    04:59

    Author Spotlight: Exploring the Effects of Transauricular Vagus Nerve Stimulation

    Published on: January 19, 2024

    3.5K
    Laboratory Administration of Transcutaneous Auricular Vagus Nerve Stimulation taVNS: Technique, Targeting, and Considerations
    06:31

    Laboratory Administration of Transcutaneous Auricular Vagus Nerve Stimulation taVNS: Technique, Targeting, and Considerations

    Published on: January 7, 2019

    41.1K
    Transauricular Vagus Nerve Stimulation and Electroencephalographic Assessment in Disorders of Consciousness
    04:04

    Transauricular Vagus Nerve Stimulation and Electroencephalographic Assessment in Disorders of Consciousness

    Published on: July 11, 2025

    1.2K

    Area of Science:

    • Neuroscience
    • Biomedical Engineering
    • Medical Devices

    Background:

    • Percutaneous electrical stimulation of the auricular vagus nerve (pVNS) is an electroceutical technology.
    • Current selection of stimulation patterns is empirical, risking under- or over-stimulation.
    • Optimizing pVNS requires assessing stimulation pattern efficiency against individual perception and computational models.

    Purpose of the Study:

    • To evaluate the efficiency of different pVNS stimulation patterns (monophasic, biphasic, triphasic).
    • To compare subjective perception with in-silico ear model data.
    • To identify optimized pVNS settings for improved therapeutic outcomes.

    Main Methods:

    • Volunteers were tested with monophasic (MS), biphasic (BS), and triphasic stimulation (TS) patterns.
    • Clinically relevant perception levels were assessed experimentally.
    • In-silico human ear models with embedded fibers and vessels were used to assess excitation levels.

    Main Results:

    • Triphasic stimulation (TS) demonstrated superiority over BS and MS in reaching perception levels.
    • TS required significantly lower magnitudes (57% of BS, 35% of MS) for comfortable perception.
    • Experimental thresholds decreased with bursted stimulation, while burst length had no influence in numerical models.
    • TS yielded the highest number of asynchronous action impulses.

    Conclusions:

    • The novel TS pattern is favored by the comparison of experimental and numerical data.
    • The study differentiates peripheral excitatory pVNS effects (in-silico) from combined peripheral and central effects (experimental).
    • This approach transitions pVNS from empirical selection to efficient, optimized settings.