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Updated: Jan 4, 2026
Single Molecule Analysis of Laser Localized Psoralen Adducts
Published on: April 20, 2017
A newly identified photolyase from Arthrospira platensis possesses a unique methenyltetrahydrofolate
Hui Yan1, Kongfu Zhu1, Maikun Teng1
1Hefei National Laboratory for Physical Sciences at Microscale, National Synchrotron Radiation Laboratory, School of Life Sciences, University of Science and Technology of China, Hefei, China.
Abstract:
Cyclobutane pyrimidine dimers (CPD), as a common DNA damage caused by UV radiation, often lead to skin cancer. Here, we identified a photolyase from the alga Arthrospira platensis (designated as Ap-phr), which has been regarded as a safe organism for humans for centuries, that can efficiently repair CPD lesions in ssDNA and dsDNA in vitro. The 1.6 Å resolution crystal structure of Ap-phr revealed that it possesses a unique methenyltetrahydrofolate chromophore-binding pattern with high energy transfer efficiency. Our study of Ap-phr highlights its potential use in cosmetic, industrial and aesthetic medicine applications.
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