Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Data Collection by Experiments01:13

Data Collection by Experiments

26.8K
Data collection is a systematic method of obtaining, observing, measuring, and analyzing accurate information. An experimental study is a standard method of data collection that involves the manipulation of the samples by applying some form of treatment prior to data collection. It refers to manipulating one variable to determine its changes on another variable. The sample subjected to treatment is known as “experimental units.”
An example of the experimental method is a public...
26.8K
Measuring Reaction Rates03:09

Measuring Reaction Rates

28.5K
Polarimetry finds application in chemical kinetics to measure the concentration and reaction kinetics of optically active substances during a chemical reaction. Optically active substances have the capability of rotating the plane of polarization of linearly polarized light passing through them—a feature called optical rotation. Optical activity is attributed to the molecular structure of substances. Normal monochromatic light is unpolarized and possesses oscillations of the electrical...
28.5K
Randomized Experiments01:13

Randomized Experiments

8.8K
The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
8.8K
Quantitative Aspects of Drug-Receptor Interaction01:30

Quantitative Aspects of Drug-Receptor Interaction

1.7K
The receptor occupancy theory connects a drug's response to the number of occupied receptors. With higher drug concentrations, more receptors are occupied, leading to increased responses. The formation of drug-receptor complexes involves association and dissociation rates, which reach equilibrium when the forward and backward reactions are equal. The equilibrium association constant (Ka) and its inverse, the equilibrium dissociation constant (Kd), indicate drug affinity. Higher Ka and lower...
1.7K
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

3.8K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
3.8K
Systematic Sampling Method01:17

Systematic Sampling Method

12.4K
Sampling is a technique to select a portion (or subset) of the larger population and study that portion (the sample) to gain information about the population. Data are the result of sampling from a population. The sampling method ensures that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
Systematic sampling is one of the simplest methods...
12.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The introduction of an intestinal ultrasound service is associated with significantly reduced endoscopy usage in an inflammatory bowel disease service-the SCOPELESS study.

Journal of Crohn's & colitis·2026
Same author

Serial Spatial Transcriptomics Reveal Divergent Routes to Therapy Resistance in Metastatic Breast Cancer.

Research square·2026
Same author

Adapting the Utrecht-Management of Identity Commitments Scale to Assess Recovery Identity: Results from a Study of Collegiate Recovery Students in North America.

Substance use & misuse·2026
Same author

Tumor-immune trajectory context connects static tissue architecture to clinical outcomes.

bioRxiv : the preprint server for biology·2026
Same author

Examining attitudes to intestinal ultrasound in inflammatory bowel disease: a national survey of Australian gastroenterologists.

Therapeutic advances in gastroenterology·2026
Same author

Treatment resistance to platinum-based chemotherapy in lung and ovarian cancer is driven by a targetable TGFβ senescent secretome.

Nature aging·2026
Same journal

OpenIMC: an open-source platform for analyzing single-cell and spatial proteomics by imaging mass cytometry.

BMC bioinformatics·2026
Same journal

NAP: an open source pipeline for cross-domain microbiome profiling using Nanopore sequencing-derived amplicon data.

BMC bioinformatics·2026
Same journal

SurvGME: an R package for survival analysis with graphical and measurement error models.

BMC bioinformatics·2026
Same journal

SimMapNet: a Bayesian framework for gene regulatory network inference using gene ontology similarities as external hint.

BMC bioinformatics·2026
Same journal

Dual channel drug-drug interactions extraction based on cross attention.

BMC bioinformatics·2026
Same journal

FeSseqdb: a curated sequence-level database and interpretable machine learning framework for identifying iron-sulfur proteins.

BMC bioinformatics·2026
See all related articles

Related Experiment Video

Updated: Jan 4, 2026

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods
05:34

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods

Published on: June 6, 2025

1.5K

Annot: a Django-based sample, reagent, and experiment metadata tracking system.

Elmar Bucher1, Cheryl J Claunch1, Derrick Hee1

  • 1Department of Biomedical Engineering and OHSU Center for Spatial Systems Biomedicine, OHSU, Portland, OR, 97201, USA.

BMC Bioinformatics
|November 3, 2019
PubMed
Summary
This summary is machine-generated.

Annot is a new web application that simplifies tracking experimental metadata for biological studies. It ensures consistent annotation of samples, reagents, and protocols, enhancing data integration and analysis for complex experiments.

Keywords:
AnnotamentumAnnotationControlled vocabularyMetadataSoftware

More Related Videos

Shotgun Proteomics Sample Processing Automated by an Open-Source Lab Robot
10:12

Shotgun Proteomics Sample Processing Automated by an Open-Source Lab Robot

Published on: October 28, 2021

4.2K
Isolation of Mandibular Gland Reservoir Contents from Bornean 'Exploding Ants' Formicidae for Volatilome Analysis by GC-MS and MetaboliteDetector
11:07

Isolation of Mandibular Gland Reservoir Contents from Bornean 'Exploding Ants' Formicidae for Volatilome Analysis by GC-MS and MetaboliteDetector

Published on: August 26, 2018

9.1K

Related Experiment Videos

Last Updated: Jan 4, 2026

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods
05:34

Applying Cheminformatics to Develop a Structure Searchable Database of Analytical Methods

Published on: June 6, 2025

1.5K
Shotgun Proteomics Sample Processing Automated by an Open-Source Lab Robot
10:12

Shotgun Proteomics Sample Processing Automated by an Open-Source Lab Robot

Published on: October 28, 2021

4.2K
Isolation of Mandibular Gland Reservoir Contents from Bornean 'Exploding Ants' Formicidae for Volatilome Analysis by GC-MS and MetaboliteDetector
11:07

Isolation of Mandibular Gland Reservoir Contents from Bornean 'Exploding Ants' Formicidae for Volatilome Analysis by GC-MS and MetaboliteDetector

Published on: August 26, 2018

9.1K

Area of Science:

  • Biological Sciences
  • Bioinformatics
  • Data Management

Background:

  • Comprehensive experimental metadata tracking is challenging in biological experiments, particularly with multiple scientists involved.
  • Annotation of experiments, reagents, and protocols using controlled vocabularies from ontologies is often difficult to implement consistently.

Purpose of the Study:

  • To introduce Annot, a novel web application designed for flexible and comprehensive experimental metadata tracking.
  • To provide a robust solution for annotating samples, reagents, and protocols in complex biological experiments involving multiple researchers.

Main Methods:

  • Annot utilizes a JSON syntax-compatible file format for detailed metadata capture.
  • The application enforces controlled vocabulary for annotation, ensuring data consistency.
  • Data can be easily exported to formats compatible with R and Pandas for analysis.

Main Results:

  • Annot enables robust tracking of investigations, studies, and protocols.
  • It facilitates the capture of detailed metadata for all aspects of complex biological experiments.
  • The JSON format allows seamless data portability for downstream analysis.

Conclusions:

  • Annot provides a robust framework for annotating samples, reagents, and protocols, especially in multi-scientist assays.
  • It enhances the integration and joint analysis of data generated across different experiments.
  • This metadata tracking solution improves the utility of large-scale biological datasets, as demonstrated in a microarray study.