Related Experiment Video

Updated: Jan 4, 2026

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
04:09

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

3.6K

Risk factors for major amputation in hospitalized diabetic patients with forefoot ulcers

Kyung-Chul Moon1, Soo-Byn Kim1, Seung-Kyu Han1

  • 1Department of Plastic Surgery, Korea University Guro Hospital, Seoul, South Korea.

Diabetes Research and Clinical Practice
|November 3, 2019
PubMed

Insights

Male gender, high magnesium, high platelets, and low HbA1c are key risk factors for major amputation in diabetic foot ulcer patients. Understanding these factors aids in preventing limb loss for individuals with diabetes.

Area of Science:

  • Endocrinology
  • Vascular Surgery
  • Diabetology

Background:

  • Diabetic foot ulcers are a significant cause of morbidity and mortality.
  • Major amputation is a devastating complication, impacting quality of life and survival.

Purpose of the Study:

  • To identify independent risk factors for major amputation in hospitalized patients with diabetic forefoot ulcers.

Main Methods:

  • Retrospective analysis of 1032 diabetic patients with forefoot ulcers admitted between 2003-2018.
  • Collected data on 88 potential risk factors, including demographics, ulcer characteristics, and serological markers.
  • Utilized univariate and stepwise multiple logistic regression to identify significant predictors of amputation.

Main Results:

  • Four factors remained significant predictors in multivariate analysis: male gender, elevated magnesium, elevated platelets, and decreased glycated hemoglobin (HbA1c).
  • Male gender (OR 8.216) and increased magnesium (OR 2.480) were associated with higher amputation risk.
  • Increased platelet count (OR 1.009) showed a slight association, while lower HbA1c (OR 0.570) was protective.

Conclusions:

  • Male gender, elevated serum magnesium, and elevated platelet levels are significant risk factors for major amputation in diabetic forefoot ulcer patients.
  • Lower levels of glycated hemoglobin (HbA1c) appear to be protective against major amputation.
  • These findings can inform targeted interventions to reduce amputation rates in this vulnerable population.
Abstract

Keywords:
AmputationDiabetic footFoot ulcerRisk analysisRisk factors

More Related Videos

A Simplified Technique for Producing an Ischemic Wound Model12:00

A Simplified Technique for Producing an Ischemic Wound Model

Published on: May 2, 2012

17.7K
Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise05:06

Author Spotlight: Integrating Tai Chi with Mindfulness Training to Achieve an Effective Mind-Body Exercise

Published on: July 14, 2023

2.3K

Related Concept Videos

Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
329
Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
295
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
302
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.0K
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
269
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.2K