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Facile Preparation of Internally Self-assembled Lipid Particles Stabilized by Carbon Nanotubes
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Solid lipid nanoparticles self-assembled from spray dried microparticles.

Brenda Sanchez-Vazquez1, Jong Bong Lee2, Margarita Strimaite1

  • 1UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.

International Journal of Pharmaceutics
|November 3, 2019
PubMed
Summary
This summary is machine-generated.

We developed a novel method for creating drug-loaded solid lipid nanoparticles (SLNs) using spray-dried microparticles. These SLNs offer stable, on-demand delivery of both hydrophobic and hydrophilic drugs, improving therapeutic outcomes.

Keywords:
Drug delivery systemSelf-assemblySolid lipid nanoparticleSpray-dryingStability

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Pharmaceutical Sciences

Background:

  • Solid lipid nanoparticles (SLNs) are promising drug delivery systems but suffer from poor storage stability.
  • Developing stable and effective SLN formulations for both hydrophobic and hydrophilic drugs remains a challenge.

Purpose of the Study:

  • To report a novel method for fabricating drug-loaded SLNs from spray-dried microparticles.
  • To evaluate the self-assembly, drug release, and cellular uptake of these SLNs.
  • To assess the therapeutic efficacy of SLN formulations for indomethacin and 5-fluorouracil.

Main Methods:

  • Spray drying of poly(vinylpyrrolidone) (PVP) microparticles loaded with glyceryl tristearate (GTS) and either indomethacin (IMC) or 5-fluorouracil (5-FU).
  • Self-assembly of SLNs upon addition of spray-dried microparticles to water.
  • In vitro characterization of SLN drug release profiles and permeation studies.
  • Assessment of cell death induction by SLN formulations compared to pure drugs.

Main Results:

  • Spray-dried microparticles readily self-assembled into SLNs in water, releasing GTS and entrapped drugs.
  • The SLNs demonstrated extended drug release profiles (>24 hours) for both IMC and 5-FU.
  • Permeation studies showed accumulation of drug cargo within cancer cells, improving local intestinal delivery.
  • SLN formulations were as effective as pure drugs in inducing cancer cell death.

Conclusions:

  • A simple and stable method for fabricating drug-loaded SLNs using spray-dried microparticles has been established.
  • These SLNs offer a versatile, non-toxic platform for delivering both hydrophobic and hydrophilic drugs with improved therapeutic potential.
  • The on-demand assembly circumvents storage stability issues, presenting a significant advancement in SLN formulation technology.