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Immunotransplant: Preventing Unintended Consequences

Stephen M Ansell1

  • 1Division of Hematology, Mayo Clinic, Rochester, Minnesota. ansell.stephen@mayo.edu.

Cancer Discovery
|November 3, 2019
PubMed

T-cell transfer into lymphodepleted recipients results not only in homeostatic activation of the infused cells but also in T-cell inhibition due to upregulation of immune checkpoint receptors including PD-1 and CTLA4, thereby mitigating T-cell efficacy. Dual checkpoint blockade of PD-1 and CTLA4 in conjunction with lymphodepletion-an "immunotransplant"-uncouples the T-cell inhibition from activation and amplifies the T-cell antitumor immune response.See related article by Marshall et al., p. 1520.

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