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Effects of physical activity and sedentary behaviour on cardiometabolic risk factors and cognitive function in
Yajie Lv1, Li Cai1, Zhaohuan Gui1
1Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Insights
This study investigates how physical activity (PA) and sedentary behavior (SB) impact children's cardiometabolic health and cognitive function, exploring underlying brain mechanisms through a long-term school-based cohort. Findings will clarify these crucial relationships in youth.
Area of Science:
- Pediatric Health Research
- Neuroscience and Cognition
- Public Health and Epidemiology
Background:
- Physical activity (PA) and sedentary behavior (SB) are linked to cardiometabolic risk factors and cognitive function, but associations in children are inconsistent.
- Cardiometabolic risk factors also affect cognitive function, yet research in pediatric populations remains limited.
- Brain-level mechanisms underlying these associations require further elucidation.
Purpose of the Study:
- To explore the independent and combined associations of PA and SB with cardiometabolic risk factors and cognitive function in children.
- To investigate the brain-level mechanisms linking PA and SB to cardiometabolic health and cognitive function in children.
- To provide evidence for targeted interventions promoting healthy lifestyles in school-aged children.
Main Methods:
- A school-based prospective cohort study involving 8324 primary school students (aged 7-12) in Guangzhou, China.
- Data collection includes questionnaires for PA, SB, and cognitive function, anthropometric and biochemical measurements, accelerometry, cognitive tasks, and electroencephalogram (EEG) for event-related potentials.
- Participants are followed up every two years from 2017 to 2026, with standardized procedures at baseline and follow-up.
Main Results:
- Data collection is ongoing; results will be published upon study completion.
- The study design allows for the examination of longitudinal associations and potential causal pathways.
- Analysis will differentiate effects of PA and SB, and their combined impact on health outcomes.
Conclusions:
- This study will clarify the complex relationships between physical activity, sedentary behavior, cardiometabolic risk, and cognitive function in children.
- Understanding the underlying brain mechanisms is crucial for developing effective public health strategies.
- Findings are expected to inform interventions aimed at improving children's long-term health and cognitive development.
Introduction:
Although studies showed that physical activity (PA) and sedentary behaviour (SB) were associated with cardiometabolic risk factors and cognitive function, both independent and combined associations among them are inconsistent. Cardiometabolic risk factors are also associated with cognitive function, but research of children is limited. Additionally, the brain level mechanisms have not been fully established. The proposed study aims to explore the associations and mechanisms of PA and SB on cognitive function and cardiometabolic risk factors in children.
Methods And Analysis:
This is a school-based prospective cohort study. A total of 8324 participants of this study are primary school students aged 7-12 years old who are followed up every 2 years from January 2017 to December 2026. We used a stratified cluster random sampling to select five primary schools in Guangzhou, China. There are three phases at baseline. At phase I, we collect PA, SB and cognitive function by questionnaires and also conduct anthropometric and biochemical measurements in all participants. At phase II, PA, SB and cognitive function are measured respectively by accelerometers and cognitive tasks among participants randomly selected from four subgroups with different SB and PA levels. At phase III, event-related potentials are recorded using electroencephalogram during a cognitive task among participants randomly selected from phase II. We plan to follow-up all participants until they graduate from high school. The process applied at baseline and follow-up are approximately identical.
Ethics And Dissemination:
Procedures described in this manuscript have been approved by the Ethical Review Committee for Biomedical Research, School of Public Health, Sun Yat-sen University (L2016-010). All parents or guardians of participants signed the informed consent form voluntarily before participating in the study. The findings of the study will be published in peer-reviewed journals.
Trial Registration Number:
NCT03582709.
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