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Updated: Jan 4, 2026

Assessment of the Metabolic Profile of Primary Leukemia Cells
Published on: November 21, 2018
Metabolic dependencies and vulnerabilities in leukemia
Marissa Rashkovan1, Adolfo Ferrando1,2,3
1Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA.
Abstract:
Leukemia cell proliferation requires up-regulation and rewiring of metabolic pathways to feed anabolic cell growth. Oncogenic drivers directly and indirectly regulate metabolic pathways, and aberrant metabolism is central not only for leukemia proliferation and survival, but also mediates oncogene addiction with significant implications for the development of targeted therapies. This review explores leukemia metabolic circuitries feeding anabolism, redox potential, and energy required for tumor propagation with an emphasis on emerging therapeutic opportunities.
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