Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

3.3K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.3K
iPS Cell Differentiation01:22

iPS Cell Differentiation

3.0K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.0K
Stem Cell Culture01:17

Stem Cell Culture

6.0K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
6.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Workload-induced changes to cell state contribute to β-cell failure in diabetes.

bioRxiv : the preprint server for biology·2026
Same author

The functional landscape of the human ubiquitinome.

bioRxiv : the preprint server for biology·2025
Same author

Single-cell multiome and spatial profiling reveals pancreas cell type-specific gene regulatory programs driving type 1 diabetes progression.

bioRxiv : the preprint server for biology·2025
Same author

Systemic LSD1 Inhibition Prevents Aberrant Remodeling of Metabolism in Obesity.

Diabetes·2022
Same author

Sizing up beta cells made from stem cells.

Nature biotechnology·2022
Same author

Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors.

Nature communications·2021

Related Experiment Video

Updated: Jan 4, 2026

Differentiation of Human Pluripotent Stem Cells Into Pancreatic Beta-Cell Precursors in a 2D Culture System
10:12

Differentiation of Human Pluripotent Stem Cells Into Pancreatic Beta-Cell Precursors in a 2D Culture System

Published on: December 16, 2021

3.2K

Human stem cell models: lessons for pancreatic development and disease.

Bjoern Gaertner1, Andrea C Carrano1, Maike Sander1

  • 1Departments of Pediatrics and Cellular & Molecular Medicine, Pediatric Diabetes Research Center, University of California, San Diego, La Jolla, California 92093, USA.

Genes & Development
|November 3, 2019
PubMed
Summary

Human pluripotent stem cell (hPSC) models are crucial for understanding pancreatic development and disease. Studies using these models reveal how gene regulation and mutations contribute to pancreatic disorders and diabetes.

Keywords:
embryonicpancreatic developmentstem cell

More Related Videos

Efficient Generation of Pancreas/Duodenum Homeobox Protein 1+ Posterior Foregut/Pancreatic Progenitors from hPSCs in Adhesion Cultures
08:32

Efficient Generation of Pancreas/Duodenum Homeobox Protein 1+ Posterior Foregut/Pancreatic Progenitors from hPSCs in Adhesion Cultures

Published on: March 27, 2019

6.4K
Efficient Differentiation of Pluripotent Stem Cells to NKX6-1+ Pancreatic Progenitors
09:23

Efficient Differentiation of Pluripotent Stem Cells to NKX6-1+ Pancreatic Progenitors

Published on: March 7, 2017

8.3K

Related Experiment Videos

Last Updated: Jan 4, 2026

Differentiation of Human Pluripotent Stem Cells Into Pancreatic Beta-Cell Precursors in a 2D Culture System
10:12

Differentiation of Human Pluripotent Stem Cells Into Pancreatic Beta-Cell Precursors in a 2D Culture System

Published on: December 16, 2021

3.2K
Efficient Generation of Pancreas/Duodenum Homeobox Protein 1+ Posterior Foregut/Pancreatic Progenitors from hPSCs in Adhesion Cultures
08:32

Efficient Generation of Pancreas/Duodenum Homeobox Protein 1+ Posterior Foregut/Pancreatic Progenitors from hPSCs in Adhesion Cultures

Published on: March 27, 2019

6.4K
Efficient Differentiation of Pluripotent Stem Cells to NKX6-1+ Pancreatic Progenitors
09:23

Efficient Differentiation of Pluripotent Stem Cells to NKX6-1+ Pancreatic Progenitors

Published on: March 7, 2017

8.3K

Area of Science:

  • Developmental Biology
  • Stem Cell Biology
  • Genetics and Genomics
  • Endocrinology

Background:

  • Understanding human cell development and function necessitates effective human cell models.
  • Human pluripotent stem cells (hPSCs) can be differentiated into pancreatic endocrine and exocrine cells.
  • These differentiation protocols mimic in vivo pancreatic development.

Purpose of the Study:

  • To review recent insights gained from pancreatic hPSC models.
  • To discuss the application of these models in deciphering pancreatic development and disease mechanisms.
  • To highlight the role of genome-scale analyses in understanding pancreatic development and disease.

Main Methods:

  • Differentiation of hPSCs into pancreatic cell types.
  • Genome-scale analyses (e.g., transcriptomics, epigenomics) of differentiation systems.
  • Analysis of hPSC models carrying disease-relevant mutations.

Main Results:

  • Genome-scale analyses elucidate the roles of chromatin state, transcription factors, and noncoding RNAs in pancreatic development.
  • Studies of hPSC models with disease mutations provide insights into the molecular basis of genetically determined pancreatic diseases.
  • Pancreatic hPSC models have been instrumental in studying congenital pancreatic defects, diabetes, and exocrine diseases.

Conclusions:

  • Pancreatic hPSC models are powerful tools for advancing the understanding of pancreatic development and disease.
  • Integration of differentiation protocols with genome-scale analyses and disease modeling offers comprehensive mechanistic insights.
  • These models hold significant promise for future research into pancreatic health and disease.