Recurrent Sinopulmonary Infections in a Patient Whose HIV Masked Common Variable Immunodeficiency
D Gollapudi1, M O'Donnell2, M NeSmith3
1Division of General Internal Medicine, Harborview Medical Center, University of Washington, Seattle, WA, 98104, USA.
Journal of General Internal Medicine
|November 3, 2019
Summary
This case study highlights a rare instance of common variable immunodeficiency (CVID) in a patient with human immunodeficiency virus (HIV). Recognizing this dual diagnosis is crucial for managing recurrent infections in immunocompromised individuals.
Area of Science:
- Immunology
- Infectious Diseases
- Clinical Medicine
Background:
- Human immunodeficiency virus (HIV) infection typically impairs cell-mediated immunity by destroying CD4+ lymphocytes, increasing infection risk.
- While immunoglobulin elevations are common in HIV, rare cases of quantitative immunoglobulin deficiency exist.
- Recurrent severe respiratory infections can indicate underlying immunodeficiency.
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